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MABC42 | Anti-Pleiotrophin Antibody, clone 3B10

50 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC, WB M Purified Monoclonal Antibody
      Catalogue NumberMABC42
      DescriptionAnti-Pleiotrophin Antibody, clone 3B10
      Alternate Names
      • pleiotrophin
      • neurite growth-promoting factor 1
      • Heparin-binding brain mitogen
      • heparin binding growth factor 8
      • Heparin-binding growth-associated molecule
      • heparin affin regulatory protein
      • Heparin-binding neurite outgrowth-promoting factor 1
      • pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
      • Osteoblast-specific factor 1
      • Heparin-binding growth factor 8
      Background InformationPleiotrophin (PTN) also called Neurite Growth-promoting Factor 1 (NEGF1) or HARP (Heparin affin regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN plays an important role in development processess and promotion of neurite extension. During embryonic development, pleiotrophin is expressed in the central and peripheral nervous system, lung, kidney, gut and bone. Pleiotrophin is also expressed by several tumor cells and is thought to be involved in tumor angiogenesis. PTN initiates an angiogenic switch in different cancer models and acts as an angiogenic factor. PTN does this through an interaction with endothelial cells to initiate proliferation, migration, and tube formation.
      Product Information
      • Human placenta tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing PBS without 0.05% sodium azide.
      ApplicationThis Anti-Pleiotrophin Antibody, clone 3B10 is validated for use in IH, WB for the detection of Pleiotrophin.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a previous lot detected Pleiotrophin in papillary squamous cell carcinoma tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to chicken Pleiotrophin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OSF-1
      • PTN
      • NEGF1
      • HBNF-1
      • HBBM
      • HBGF8
      • HBGF-8
      • HBNF1
      • HB-GAM
      • HARP
      • HBNF1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Heparin binding mitogenic protein. Has neurite extension activity.


      SEQUENCE SIMILARITIES: Belongs to the pleiotrophin family.
      Molecular Weight~20 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human placenta tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Pleiotrophin in 10 µg of human placenta tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information