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MABT394 | Anti-Plakophilin-2 Antibody, clone 8H6

MABT394
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABT394
      DescriptionAnti-Plakophilin-2 Antibody, clone 8H6
      Alternate Names
      • Plakophilin-2
      Background InformationPlakophilin-2 (PKP2) is a member of the Armadillo/β-catenin family. It contains eight ARM repeats and can exist in two slice isoforms (2a and 2b). Plakophilin-2 is highly abundant in simple and stratified epithelial cells; but is also expressed in non-epithelial cells, such as the myocardium and lymph node follicles. In epithelial cells, it is localized to desmosomal plaques and plays an important role in cell-cell adhesion processes. Plakophilin-2 also maintains the cell-cell junctions of cardiac tissue, and is essential for proper cardiac function. Mutations in the plakophilin-2 gene cause arrhythmogenic right ventricular cardiomyopathy 9, a condition characterized by partial breakdown of the myocardium of the right ventricle, electrical instability, and sudden death. Plakophilin-2 has also been implicated in the development of cancer.
      References
      Product Information
      FormatPurified
      Control
      • A431 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Plakophilin-2 Antibody, clone 8H6 detects level of Plakophilin-2 & has been published & validated for use in Western Blotting, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot was used by an independent laboratory in A431 and UM-SCC-38 cells. (Sobolik-Delmaire, T., et al. (2010). Journal of Investigative Dermatology. 130:2638–2646.)
      Biological Information
      ImmunogenMBP-tagged recombinant protein corresponding to human Plakophilin-2.
      Clone8H6
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PKP2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~97 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in A431 cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected Plakophilin-2 in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Plakophilin-2, clone 8H6 - Q2057897 Q2057897
      Anti-Plakophilin-2, clone 8H6 -2716774 2716774
      Anti-Plakophilin-2, clone 8H6 -2819129 2819129

      References

      Reference overviewPub Med ID
      Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA.
      Sobolik-Delmaire, Tammy, et al.
      J. Invest. Dermatol., 130: 2638-46 (2010) 2010

      Show Abstract
      20613778 20613778

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies