MABN505 | Anti-Pink1 Antibody, clone N4/15

MABN505
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN505
      DescriptionAnti-Pink1 Antibody, clone N4/15
      Alternate Names
      • Serine/threonine-protein kinase PINK1, mitochondrial
      • BRPK
      • PTEN-induced putative kinase protein 1
      Background InformationMutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson's disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
      References
      Product Information
      FormatPurified
      Control
      • Human skeletal muscle tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Pink1 Antibody, clone N4/15 is a highly specific mouse monoclonal antibody & that targets PINK1 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected Pink1 in 10 µg of human testis tissue lysate.

      Immunohistochemistry Analysis: A representative lot detected Pink1 in rat caudate putamen tissue (Prof. J. Trimmer, University of California, Davis.).
      Biological Information
      ImmunogenRecombinant protein corresponding to the cytoplasmic domain of human Pink1.
      EpitopeCytoplasmic domain
      CloneN4/15
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes the cytoplasmic domain of Pink1. Other Homologies: Mouse (81% Sequence Homology) and Rat (82% Sequence Homology)
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PINK1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~60 kDa observed. Uniprot describes two isoforms at 63 kDa and 30 kDa. The full length protein of Pink1 is observed at 63 kDa is the full length PINK1; however, it is proteolytically cleaved to a ~52 kDa form upon entry into the mitochondria (Jin, S. M., et al. (2010). J Cell Biol. 191(5):933-942.).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human skeletal muscle tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pink1 in 10 µg of human skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies