16-256 Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor® 488

16-256
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Vrt FC M AlexaFluor®488 Monoclonal Antibody
      Description
      Catalogue Number16-256
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor® 488
      OverviewSignificance:
      Anti-Phosphatidylserine may be used to detect translocation of the membrane phospholipid phosphatidylserine (PS) from the inner to the outer cell membrane leaflet; it provides an alternative to Annexin V for quantitation of apoptosis.
      Background InformationPhosphatidylserine, or PS, is a naturally occurring, phospholipid nutrient. PS is essential to the functioning of all the cells of the body, but is most concentrated in the brain. Its relative abundance in this organ reflects its proven involvement in an assortment of nerve cell functions, including nerve transmitter release and synaptic activity. Clinical studies have suggested that PS can support brain functions that tend to decline with age.
      References
      Product Information
      FormatAlexaFluor®488
      Control
      • Staurosporine treated Jurkat cells.
        Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG.
      PresentationPurified mouse monoclonal IgG in buffer containing PBS containing 1% BSA, 0.05% Tween, 0.05% sodium azide. Liquid at 4ºC.
      Applications
      ApplicationDetect Phosphatidylserine using this Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor 488 validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenLiposomes containing 70% phosphatidylserine and 30% phosphatidylglycerol.
      Cloneclone 1H6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes phosphatidylserine (PS) in cell membranes.
      IsotypeIgG
      Species Reactivity
      • Vertebrates
      Antibody TypeMonoclonal Antibody
      Modifications
      • Phosphorylation
      Purification MethodProtein G Purified
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceFlow Cytometry: 0.2 μg of this antibody detected Phosphatidylserine in fixed Jurkat cells (see page 2).

      Apoptosis Assay: Time course for induction of apoptosis in Jurkat cells by staurosporine, measured using either an Anti-Phosphatidylserine, clone 1H6, Alexa Fluor® 488 conjugate or an Annexin V FITC conjugate.
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor® 488 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor® 488 Certificates of Analysis

      TitleLot Number
      Anti-Phosphatidylserine, clone 1H6, -26812072681207
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - 20318052031805
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - 21671392167139
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - 4200042000
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - DAM1524042DAM1524042
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - JBC1883037JBC1883037
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - JBC1916944JBC1916944
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluor#174; 488 conjugate - NG1944035NG1944035
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluorreg; 488 conjugate - 3056830568
      Anti-Phosphatidylserine, clone 1H6, Alexa Fluorreg; 488 conjugate - 4100041000

      References

      Reference overviewApplicationPub Med ID
      Metabolism and functions of phosphatidylserine.
      Vance, Jean E and Steenbergen, Rineke
      Prog. Lipid Res., 44: 207-34 (2005)  2005

      Show Abstract
      15979148 15979148
      The role of phosphatidylserine in recognition and removal of erythrocytes.
      Kuypers, F A and de Jong, K
      Cell. Mol. Biol. (Noisy-le-grand), 50: 147-58 (2004)  2004

      Show Abstract
      15095785 15095785
      Early membrane events in polymorphonuclear cell (PMN) apoptosis: membrane blebbing and vesicle release, CD43 and CD16 down-regulation and phosphatidylserine externalization.
      Nusbaum, P, et al.
      Biochem. Soc. Trans., 32: 477-9 (2004)  2004

      Show Abstract
      15157165 15157165
      Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal.
      Botto, Marina
      Arthritis Res. Ther., 6: 147-50 (2004)  2004

      15225357 15225357
      Hide and seek: the secret identity of the phosphatidylserine receptor.
      Williamson, Patrick and Schlegel, Robert A
      J. Biol., 3: 14 (2004)  2004

      Show Abstract
      15453906 15453906
      Exposure of platelet membrane phosphatidylserine regulates blood coagulation.
      Lentz, Barry R
      Prog. Lipid Res., 42: 423-38 (2003)  2003

      Show Abstract
      12814644 12814644
      Apoptosis: giving phosphatidylserine recognition an assist--with a twist.
      Fadok, Valerie A and Henson, Peter M
      Curr. Biol., 13: R655-7 (2003)  2003

      12932346 12932346
      Copper chelation represses the vascular response to injury
      Mandinov, L., et al
      Proc Natl Acad Sci U S A, 100:6700-5 (2003)  2003

      Immunohistochemistry (Tissue)12754378 12754378
      A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.
      Vermes, I, et al.
      J. Immunol. Methods, 184: 39-51 (1995)  1995

      Show Abstract
      7622868 7622868

      Related Products & Applications

      Alternative Format

      Catalog Number Description  
      05-719 Anti-Phosphatidylserine Antibody, clone 1H6 Show Pricing & Availability

      Included Negative Control

      Catalog Number Description  
      16-240 Normal Mouse IgG, Alexa Fluor® 488 conjugate Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies