MAB1572 Anti-Parvalbumin Antibody

MAB1572
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ca, F, Fe, Fg, Gt, H, M, Po, R, Rb ICC, IH(P), WB M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB1572
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Parvalbumin Antibody
      Background InformationParvalbumin is a calcium binding albumin protein. It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is localised in fast-contracting muscles, where its levels are highest, and in the brain and some endocrine tissues. Parvalbumin is present in GABAergic interneurons in the nervous system, predominantly expressed by chandelier and basket cells in the cortex.
      References
      Product Information
      FormatAscites
      Control
      • Brain tissue, Cultured neurons
      PresentationAscites mouse monoclonal IgG1 liquid
      Applications
      ApplicationAnti-Parvalbumin Antibody is an antibody against Parvalbumin for use in IC, IH(P) & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry:
      A previous lot was used by indirect immunoperoxidase at 1:1,000-1:2,000 dilution. The antibody works on formalin fixed, paraffin embedded tissue sections of rat cerebellum from a previous lot. Fixation does not appear to affect MAB1572’s ability to detect parvalbumin.

      Immunocytochemistry:
      A previous lot of this antibody was used on cultured neurons.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenParvalbumin purified from frog muscle
      ClonePARV-19
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityParvalbumin. The antibody will react with parvalbumin from brain and muscle. By immunoblot it recognizes a protein of 12 kDa. The antibody is directed against an epitope at the first Ca+2-binding site and specifically stains the Ca+2 -bound form of parvalbumin.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Canine
      • Fish
      • Feline
      • Frog
      • Goat
      • Human
      • Mouse
      • Pig
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation.
      Gene Symbol
      • PVALB
      • MGC116759
      • parvalbumin
      • D22S749
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20472 # In muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation.
      SIZE: 110 amino acids; 12059 Da
      SIMILARITY: SwissProt: P20472 ## Belongs to the parvalbumin family. & Contains 2 EF-hand domains.
      MISCELLANEOUS: This protein binds two calcium ions.
      Molecular Weight12 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on mouse brain lysate.

      Western Blot Analysis:
      1:1000 dilution of this lot detected Parvalbumin on 10 μg of mouse brain lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Parvalbumin3158866
      Anti-Parvalbumin - 23877432387743
      Anti-Parvalbumin - 19401011940101
      Anti-Parvalbumin - 20159662015966
      Anti-Parvalbumin - 20699412069941
      Anti-Parvalbumin - 20740262074026
      Anti-Parvalbumin - 22087642208764
      Anti-Parvalbumin - 23250382325038
      Anti-Parvalbumin - 23325012332501
      Anti-Parvalbumin - 24703882470388

      References

      Reference overviewApplicationSpeciesPub Med ID
      Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding.
      De Andrade, PB; Neff, LA; Strosova, MK; Arsenijevic, D; Patthey-Vuadens, O; Scapozza, L; Montani, JP; Ruegg, UT; Dulloo, AG; Dorchies, OM
      Frontiers in physiology  6  254  2015

      Show Abstract
      26441673 26441673
      Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
      Cooke, SF; Komorowski, RW; Kaplan, ES; Gavornik, JP; Bear, MF
      Nature neuroscience  18  262-71  2015

      Show Abstract
      25599221 25599221
      Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
      Seo, H; Seol, MJ; Lee, K
      Molecular brain  8  13  2015

      Show Abstract
      25761792 25761792
      Processing of visually evoked innate fear by a non-canonical thalamic pathway.
      Wei, P; Liu, N; Zhang, Z; Liu, X; Tang, Y; He, X; Wu, B; Zhou, Z; Liu, Y; Li, J; Zhang, Y; Zhou, X; Xu, L; Chen, L; Bi, G; Hu, X; Xu, F; Wang, L
      Nature communications  6  6756  2015

      Show Abstract
      25854147 25854147
      Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
      Hoch, RV; Clarke, JA; Rubenstein, JL
      Neural development  10  8  2015

      Show Abstract
      25889070 25889070
      Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3.
      Auer, TO; Xiao, T; Bercier, V; Gebhardt, C; Duroure, K; Concordet, JP; Wyart, C; Suster, M; Kawakami, K; Wittbrodt, J; Baier, H; Del Bene, F
      eLife  4  2015

      Show Abstract
      26076409 26076409
      Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.
      D'Agostino, G; Cristiano, C; Lyons, DJ; Citraro, R; Russo, E; Avagliano, C; Russo, R; Raso, GM; Meli, R; De Sarro, G; Heisler, LK; Calignano, A
      Molecular metabolism  4  528-36  2015

      Show Abstract
      26137440 26137440
      OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.
      Hoch, RV; Lindtner, S; Price, JD; Rubenstein, JL
      Cell reports  12  482-94  2015

      Show Abstract
      26166575 26166575
      The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.
      Stawicki, TM; Owens, KN; Linbo, T; Reinhart, KE; Rubel, EW; Raible, DW
      Disease models & mechanisms  7  847-56  2014

      Show Abstract
      24973752 24973752
      Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.
      Ding, Y; Qu, Y; Feng, J; Wang, M; Han, Q; So, KF; Wu, W; Zhou, L
      PloS one  9  e101918  2014

      Show Abstract
      ImmunohistochemistryMouse25003601 25003601

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies