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MABN624 | Anti-Pan-QKI Antibody, clone N147/6

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, H WB M Purified Monoclonal Antibody
      Catalogue NumberMABN624
      DescriptionAnti-Pan-QKI Antibody, clone N147/6
      Alternate Names
      • Protein quaking
      • Hqk
      • HqkI
      • QKI
      Background InformationQKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients.
      Product Information
      • Rat brain membrane tissue lysate.
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Pan-QKI Antibody, clone N147/6 is a highly specific mouse monoclonal antibody & that targets QKI & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pan-QKI in human frontal cortex.

      Immunohistochemistry Analysis: A representative lot detected Pan-QKI in rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis.).

      Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of rat brain tissue.

      Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of mouse brain membrane tissue.

      Western Blotting Analysis: A representative lot detected Pan-QKI in RBM cell lysates and in COS cell lysates transfected with QKI-5, QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of Califorina, Davis.).
      Biological Information
      ImmunogenRecombinant protein corresponding to human Pan-QKI.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody demonstrates cross reactivity against QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of California, Davis.).
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • QKI
      • HKQ
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~36-40 kDa observed. Uniprot describes six isoforms observed between 35-38 kDa. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain membrane tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Pan-QKI in 10 µg of rat brain membrane tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies