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05-517 | Anti-PTH/PTHrP Receptor Antibody, clone 3D1.1

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Po IHC, WB M Purified Monoclonal Antibody
      Catalogue Number05-517
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PTH/PTHrP Receptor Antibody, clone 3D1.1
      Product Information
      • Kidney Tissue
      PresentationProtein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      ApplicationAnti-PTH/PTHrP Receptor Antibody, clone 3D1.1 is an antibody against PTH/PTHrP Receptor for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 146-169 of the human PTH/PTHrP (parathyroid hormone/parathyroid hormone related protein) receptor (RRCDRNGSWELVPGHNRTWANYSE).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes PTH/PTHrP receptor and the receptor dimer.
      Species Reactivity
      • Human
      • Mouse
      • Pig
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
      Gene Symbol
      • PTHLH
      • PTHRP
      • osteostatin
      • PTHrP
      • MGC14611
      • PTHR
      • 107-139).
      • PLP
      • HHM
      • PTH-rP
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P12272 # Osteostatin is a potent inhibitor of osteoclastic bone resorption.
      SIZE: 177 amino acids; 20194 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted.
      TISSUE SPECIFICITY: Ubiquitous. Also expressed in the mammary gland.
      PTM: There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
      DISEASE:SwissProt: P12272 # Produced by many tumors from patients with HHM (humoral hypercalcemia of malignancy).
      SIMILARITY: SwissProt: P12272 ## Belongs to the parathyroid hormone family.
      Molecular Weight80 kDa; receptor dimer at 160 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on RIPA lysates of 3T3-L1 pre-adipose fibroblasts
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PTH/PTHrP Receptor, clone 3D1.1 2472929
      Anti-PTH/PTHrP Receptor, clone 3D1.1 - 0606033560 0606033560
      Anti-PTH/PTHrP Receptor, clone 3D1.1 - 19376 19376
      Anti-PTH/PTHrP Receptor, clone 3D1.1 - 20789 20789
      Anti-PTH/PTHrP Receptor, clone 3D1.1 - 27335 27335
      Anti-PTH/PTHrP Receptor, clone 3D1.1 - DAM1413931 DAM1413931
      Anti-PTH/PTHrP Receptor, clone 3D1.1 - JBC1378220 JBC1378220


      Reference overviewPub Med ID
      Control of bone formation by the serpentine receptor Frizzled-9.
      Albers, J; Schulze, J; Beil, FT; Gebauer, M; Baranowsky, A; Keller, J; Marshall, RP; Wintges, K; Friedrich, FW; Priemel, M; Schilling, AF; Rueger, JM; Cornils, K; Fehse, B; Streichert, T; Sauter, G; Jakob, F; Insogna, KL; Pober, B; Knobeloch, KP; Francke, U; Amling, M; Schinke, T
      The Journal of cell biology 192 1057-72 2011

      Show Abstract
      21402791 21402791
      Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors.
      Marzan, CV; Kupumbati, TS; Bertran, SP; Samuels, T; Leibovitch, B; Mira-y-Lopez, R; Ossowski, L; Farias, EF
      Developmental biology 349 125-36 2011

      Show Abstract
      20974122 20974122
      Cell-specific effects of nitric oxide deficiency on parathyroid hormone-related peptide (PTHrP) responsiveness and PTH1 receptor expression in cardiovascular cells.
      Rolf Schreckenberg, Sibylle Wenzel, Rui Manuel da Costa Rebelo, Anja Röthig, Rainer Meyer, Klaus-Dieter Schlüter, R Schreckenberg, S Wenzel, RM da Costa Rebelo, A Rothig, R Meyer, KD Schluter
      Endocrinology 150 3735-3741 2009

      Show Abstract
      19342458 19342458
      Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone.
      Gao, J; Tiwari-Pandey, R; Samadfam, R; Yang, Y; Miao, D; Karaplis, AC; Sairam, MR; Goltzman, D
      Endocrinology 148 2613-21 2007

      Show Abstract
      17332067 17332067

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