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MABN68 | Anti-PSD95 Antibody, clone K28/43

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, H IHC, WB, ICC M Purified Monoclonal Antibody
      Catalogue NumberMABN68
      DescriptionAnti-PSD95 Antibody, clone K28/43
      Alternate Names
      • Postsynaptic density protein 95
      • Synapse-associated protein 90
      • Tax interaction protein 15
      • discs large homolog 4
      • discs, large homolog 4 (Drosophila)
      • post-synaptic density protein 95
      Background InformationPSD95 (postsynaptic density 95) represent a class of anchoring proteins which serve to localize various neuronal ion channels to post-synaptic densities. PSD95 and related proteins contain PDZ domains, which interact with NMDA receptors and voltage-gated K+ channels via a ET/SXV motif in the cytoplasmic carboxyl terminus of the receptor channels.
      Product Information
      • Rat brain tissue lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect PSD95 using this Anti-PSD95 Antibody, clone K28/43 validated for use in IH, WB & IC.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: 1:500 dilution from a previous lot detected PSD95 in rat cortex tissue.

      Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Maeda, T., et al. (2005). Invest. Ophthalmol. Vis. Sci. 46(11):4320-4327.)
      Biological Information
      ImmunogenRecombinant protein corresponding to human PSD95.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteDemonstrated to react with rat. Predicted to react with mouse based on 100% sequence homology. Predicted to react with human based on immunogen design.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
      Gene Symbol
      • PSD-95
      • PSD95
      • SAP-90
      • SAP90
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

      SUBUNIT STRUCTURE: Interacts with ANKS1B, KLHL17 and PRR7 (By similarity). Interacts through its PDZ domains with NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A and BEGAIN. Interacts through its third PDZ domain with CRIPT (By similarity). Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with LRFN1, LRFN2 and LRFN4. Interacts with ANO2, ADAM22 and LGI1 (By similarity). Interacts with FRMPD4 (via C-terminus). Interacts (via PDZ1 and PDZ2 domains) with LRRC4; LRRC4B and SEMA4C. Interacts (via guanylate kinase-like domain) with SIPA1L1 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Cell junction › synapse › synaptosome (By similarity). Note: High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.


      DOMAIN: The PDZ domain 3 mediates interaction with ADR1B.

      The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density.

      PTM: Palmitoylation of isoform 1 is required for targeting to postsynaptic density (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the MAGUK family.

      Contains 1 guanylate kinase-like domain.

      Contains 3 PDZ (DHR) domains.

      Contains 1 SH3 domain.
      Molecular Weight ~95 kDa observed.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat brain tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected PSD95 on 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PSD95, clone K28/43 - 2145078 2145078
      Anti-PSD95, clone K28/43 - 2366034 2366034
      Anti-PSD95, clone K28/43 - 2388375 2388375
      Anti-PSD95, clone K28/43 - 2424805 2424805
      Anti-PSD95, clone K28/43 - 1947027 1947027
      Anti-PSD95, clone K28/43 - 1992665 1992665
      Anti-PSD95, clone K28/43 - 2023196 2023196
      Anti-PSD95, clone K28/43 - 2064839 2064839
      Anti-PSD95, clone K28/43 - 2216914 2216914
      Anti-PSD95, clone K28/43 - 2293538 2293538
      Anti-PSD95, clone K28/43 - 2299153 2299153
      Anti-PSD95, clone K28/43 - 2504894 2504894
      Anti-PSD95, clone K28/43 - 2509149 2509149
      Anti-PSD95, clone K28/43 - NG1872077 NG1872077
      Anti-PSD95, clone K28/43 - NG1895097 NG1895097
      Anti-PSD95, clone K28/43 - NG1928796 NG1928796
      Anti-PSD95, clone K28/43 - NRG1818965 NRG1818965
      Anti-PSD95, clone K28/43 -2677797 2677797
      Anti-PSD95, clone K28/43 -2739147 2739147
      Anti-PSD95, clone K28/43 -2762329 2762329


      Reference overviewPub Med ID
      KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.
      Pedraza, N; Ortiz, R; Cornadó, A; Llobet, A; Aldea, M; Gallego, C
      The Journal of neuroscience : the official journal of the Society for Neuroscience 34 13988-97 2014

      Show Abstract
      25319695 25319695
      Impairment of TrkB-PSD-95 signaling in Angelman syndrome.
      Cao, C; Rioult-Pedotti, MS; Migani, P; Yu, CJ; Tiwari, R; Parang, K; Spaller, MR; Goebel, DJ; Marshall, J
      PLoS biology 11 e1001478 2013

      Show Abstract
      23424281 23424281
      A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.
      Yu, WM; Appler, JM; Kim, YH; Nishitani, AM; Holt, JR; Goodrich, LV
      eLife 2 e01341 2013

      Show Abstract
      24327562 24327562
      Optimized protocol for retinal wholemount preparation for imaging and immunohistochemistry.
      Ivanova, E; Toychiev, AH; Yee, CW; Sagdullaev, BT
      Journal of visualized experiments : JoVE e51018 2013

      Show Abstract
      24379013 24379013
      Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
      Wang, Q; Green, SH
      The Journal of neuroscience : the official journal of the Society for Neuroscience 31 7938-49 2011

      Show Abstract
      21613508 21613508


      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

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