A part of MilliporeSigma

05-592 | Anti-PP2A Antibody, B subunit, clone 2G9

200 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, Po, R, Rb, Xn IHC, IP, WB M Ascites Monoclonal Antibody
      Catalogue Number05-592
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PP2A Antibody, B subunit, clone 2G9
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide and glycerol to 30%
      ApplicationDetect PP2A using this Anti-PP2A Antibody, B subunit, clone 2G9 validated for use in IH, IP & WB.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to residues 398-411 of human PP2A, B subunit
      Cloneclone 2G9
      SpecificityPP2A B subunit, isoform reactivity is α > δ,β > γ
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Pig
      • Rat
      • Rabbit
      • Xenopus
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPP2CA
      • PP2CA
      • PP2A-alpha
      • PP2Ac
      • RP-C
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFunction: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
      Subunit structure: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
      Tissue specificity: In all tissues examined.
      Post-translational modification : The N-terminus is blocked.
      Sequence similarities: Belongs to the phosphatase 2A regulatory subunit B family.
      Contains 7 WD repeats.
      Molecular Weight55kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from non-stimulated A431 cells or mouse 3T3/A31 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PP2A, B subunit, clone 2G9 (mouse ascites) - 2326374 2326374
      Anti-PP2A, B subunit, clone 2G9 (mouse ascites) - DAM1437260 DAM1437260
      Anti-PP2A, B subunit, clone 2G9 - 20265 20265
      Anti-PP2A, B subunit, clone 2G9 - DAM1810801 DAM1810801
      Anti-PP2A, B subunit, clone 2G9 - JBC1940047 JBC1940047
      Anti-PP2A, B subunit, clone 2G9 -2539262 2539262
      Anti-PP2A, B subunit, clone 2G9 -2628322 2628322
      Anti-PP2A, B subunit, clone 2G9 -2648599 2648599


      Reference overviewApplicationPub Med ID
      Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.
      Williams, BC; Filter, JJ; Blake-Hodek, KA; Wadzinski, BE; Fuda, NJ; Shalloway, D; Goldberg, ML
      eLife 3 e01695 2014

      Show Abstract
      24618897 24618897
      Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.
      Sontag, JM; Wasek, B; Taleski, G; Smith, J; Arning, E; Sontag, E; Bottiglieri, T
      Frontiers in aging neuroscience 6 214 2014

      Show Abstract
      Western Blotting25202269 25202269
      Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability.
      Keen, JC; Zhou, Q; Park, BH; Pettit, C; Mack, KM; Blair, B; Brenner, K; Davidson, NE
      The Journal of biological chemistry 280 29519-24 2005

      Show Abstract
      15965230 15965230
      Altering the holoenzyme composition and substrate specificity of protein phosphatase 2A
      Fellner, T., et al
      Methods Enzymol, 366:187-203 (2003) 2003

      Immunoprecipitation14674250 14674250
      Bestrophin interacts physically and functionally with protein phosphatase 2A
      Marmorstein, L. Y., et al
      J Biol Chem, 277:30591-7 (2002) 2002

      Immunoblotting (Western)12058047 12058047
      Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen.
      Ogris, E, et al.
      Oncogene, 15: 911-7 (1997) 1997

      Show Abstract
      9285686 9285686

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      Life Science Research > Antibodies and Assays > Primary Antibodies