A part of MilliporeSigma

MABS481 | Anti-PL Scramblase 3, clone 3B4 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB M Purified Monoclonal Antibody
      Catalogue NumberMABS481
      DescriptionAnti-PL Scramblase 3, clone 3B4 Antibody
      Alternate Names
      • Phospholipid scramblase 3
      • PL scramblase 3
      • Ca(2+)-dependent phospholipid scramblase 3
      Background InformationPhospholipid scramblase 3 (PL scramblase 3), also known as Ca(2+)-dependent phospholipid scramblase 3, and encoded by the gene name PLSCR3, is a member of the phospholipid scramblase family. Recent studies have indicated that PL scramblase 3 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. PL scramblase 3 is suggested to play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. It may also play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. PL scramblase 3 has been demonstrated to interact with PDCD6 in a calcium-dependent manner.
      Product Information
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-PL Scramblase 3 antibody is validated for use in Western Blotting for the detection of PL Scramblase 3.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected PL Scramlase 3 in SH-SY5Y cell lysate (Chu, C.T., et al. (2013). Nature Cell Biology. 15(10):1197-1205).
      Western Blotting Analysis: A representative lot detected PL Scramlase 3 in primary adipocytes lysate (Wiedmer, T., et al. (2004). PNAS. 101(36):13296-13301).
      Biological Information
      ImmunogenRecombinant protein corresponding to human PL Scramlase 3.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Plscr3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~31 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in NIH-3T3/L1 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected PL Scramlase 3 in 10 µg of NIH-3T3/L1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PL Scramblase 3, clone 3B4 - Q2488083 Q2488083


      Reference overviewPub Med ID
      Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells.
      Chu, CT; Ji, J; Dagda, RK; Jiang, JF; Tyurina, YY; Kapralov, AA; Tyurin, VA; Yanamala, N; Shrivastava, IH; Mohammadyani, D; Qiang Wang, KZ; Zhu, J; Klein-Seetharaman, J; Balasubramanian, K; Amoscato, AA; Borisenko, G; Huang, Z; Gusdon, AM; Cheikhi, A; Steer, EK; Wang, R; Baty, C; Watkins, S; Bahar, I; Bayır, H; Kagan, VE
      Nature cell biology 15 1197-205 2013

      Show Abstract
      24036476 24036476
      Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
      Wiedmer, T; Zhao, J; Li, L; Zhou, Q; Hevener, A; Olefsky, JM; Curtiss, LK; Sims, PJ
      Proceedings of the National Academy of Sciences of the United States of America 101 13296-301 2004

      Show Abstract
      15328404 15328404