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MABT887 | Anti-PL Scramblase 1 Antibody, clone 9A7

100 μg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB M Purified Monoclonal Antibody
      Catalogue NumberMABT887
      DescriptionAnti-PL Scramblase 1 Antibody, clone 9A7
      Alternate Names
      • Phospholipid scramblase 1
      • PL scramblase 1
      • Ca(2+)-dependent phospholipid scramblase 1
      • Transplantability-associated protein 1
      • NOR1
      • TRA1
      Background InformationPhospholipid scramblase 1 (UniProt Q9JJ00; also known as Ca(2+)-dependent phospholipid scramblase 1, Nor1, PL scramblase 1, Tra1, Transplantability-associated protein 1) is encoded by the Plscr1 (also known as Tra1b, Tras1) gene (Gene ID 22038) in murine species. Plasma membrane phospholipids are distributed asymmetrically between the inner and outer leaflets. Such asymmetrical distribution collapses in response to blood coagulation and apoptosis, resulting in phospholipid “scrambling” between the two leaflets of the plasma membrane. Flippases, floppases, and scramblases are three types enzymes known to mediate transbilayer lipid motion. Flippases and floppases function via ATP-dependent mechanism, while scramblases mediate transbilayer movement in a non-selective and energy-independent manner. Originally identified in 1996 as a 37 kDa erythrocyte type II transmembrane protein that mediates calcium-dependent membrane phospholipids redistribution, PL Scramblase 1 is the protein product encoded by the founding member of the PLSCR family of genes (PLSCR1-5). All PLSCR family members, with the exception of PLSCR2, possess a proline-rich N-terminal region containing PxxP and PPxY domains, a cysteine-rich region, a conserved calcium-binding domain (EF-hand-like), and a putative transmembrane region enriched in hydrophobic amino acids. In addition, PLSCR1 contains a nuclear localization signal (NLS) and a DNA-binding domain that are essential for its nuclear localization and associated nuclear function. In addition to PLSCRs, TMEM16 and XKR family members have also been reported to mediate scramblase activity.
      Product Information
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-PL Scramblase 1 Antibody, clone 9A7 is an antibody against PL Scramblase 1 Antibody for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected PL Scramblase 1 in mouse lung homogenates. Clone 9A7 also detected LPS treatment-induced PL Scramblase 1 upregulation in liver using total tissue homogenates, as well as cytosolic and nuclear extracts from LPS-treated and untreated mice (Lu, B., et al. (2007). Biochim. Biophys. Acta. 1771(9):1177-1185).
      Biological Information
      ImmunogenRecombinant protein corresponding to the cytoplasmic domain of mouse PL Scramblase 1.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityClone 9A7 reacts with murine PL Scramblase 1, and does not cross-reacts with murine PL Scramblase 2/3/4 or human PL Scramblase 1.
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Plscr1
      • Tra1b
      • Tras1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~38 kDa observed. Two additional bands shown correspond to heavy and light chains of endogenous IgG from the mouse thymus tissue.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse thymus tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected PL Scramblase 1 in 10 µg of mouse thymus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PL Scramblase 1, clone 9A7 -Q2611630 Q2611630


      Reference overviewPub Med ID
      Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.
      Lu, B; Sims, PJ; Wiedmer, T; Moser, AH; Shigenaga, JK; Grunfeld, C; Feingold, KR
      Biochimica et biophysica acta 1771 1177-85 2007

      Show Abstract
      17590392 17590392


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      Post-Translational Modifications