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06-903 | Anti-PKA Antibody, NT

06-903
200 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, Ht, M, Po, R WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number06-903
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PKA Antibody, NT
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol added to 30%
      Applications
      ApplicationAnti-PKA Antibody, NT detects level of PKA & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide (KKGSEQESVKEFLAK-C) based upon amino acids 8-22 of the human 41kDa alpha isoform of the catalytic subunit of PKA
      HostRabbit
      SpecificityPKA, and recombinant human alpha isoform of PKA
      IsotypeIgG
      Species Reactivity
      • Bovine
      • Human
      • Hamster
      • Mouse
      • Pig
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
      Gene Symbol
      • PRKACA
      • MGC102831
      • PKACA
      • MGC48865
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
      SIZE: 351 amino acids; 40590 Da
      SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
      TISSUE SPECIFICITY: Isoform 2 is sperm specific.
      PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
      SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Molecular Weight41kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat brain microsomal preparation or PC-12 RIPA cell lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PKA, NT 2484179
      Anti-PKA, NT (rabbit polyclonal IgG) - 2352368 2352368
      Anti-PKA, NT - 17905 17905
      Anti-PKA, NT - 18085 18085
      Anti-PKA, NT - 24144 24144
      Anti-PKA, NT - 27718 27718
      Anti-PKA, NT -2604232 2604232
      Anti-PKA, NT -2694626 2694626
      Anti-PKA, NT -2721667 2721667

      References

      Reference overviewPub Med ID
      PKA has a critical role in synaptic delivery of GluR1- and GluR4-containing AMPARs during initial stages of acquisition of in vitro classical conditioning.
      Zhaoqing Zheng,Joyce Keifer
      Journal of neurophysiology 101 2009

      Show Abstract Full Text Article
      19261706 19261706