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07-658 | Anti-PI3 Kinase Antibody, p110α

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Vrt IP Rb Purified Polyclonal Antibody
      Catalogue Number07-658
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PI3 Kinase Antibody, p110α
      Product Information
      ApplicationThis Anti-PI3 Kinase Antibody, p110α is validated for use in IP for the detection of PI3 Kinase.
      Key Applications
      • Immunoprecipitation
      Application NotesWestern blot NOT recommended
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide (CTTKMDWIFHTIKQHALN) corresponding to amino acids 1052-1068 of human 110kDa PI3 Kinase, with an N-terminal cysteine added for conjugation purposes
      SpecificityPI3 Kinase 110kDa alpha catalytic subunit and co-immunoprecipitates the associated 85kDa regulatory subunit
      Species Reactivity
      • Human
      • Vertebrates
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPhosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
      Gene Symbol
      • PIK3CA
      • MGC142163
      • PI3K
      • MGC142161
      • p110-alpha
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
      SIZE: 1068 amino acids; 124284 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
      DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
      SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
      Molecular Weight110kDa catalytic subunit and 85kDa regulatory subunit
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitation on RIPA lysates from EGF-stimulated A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PI3 Kinase, p110alpha; - 27155 27155
      Anti-PI3 Kinase, p110α 2477875
      Anti-PI3 Kinase, p110α - 2517342 2517342
      Anti-PI3 Kinase, p110α -2522079 2522079


      Reference overviewPub Med ID
      Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.
      del Rincon, JP; Iida, K; Gaylinn, BD; McCurdy, CE; Leitner, JW; Barbour, LA; Kopchick, JJ; Friedman, JE; Draznin, B; Thorner, MO
      Diabetes 56 1638-46 2007

      Show Abstract
      17363744 17363744
      Phosphatidylinositol 3-kinase.
      Kapeller, R and Cantley, L C
      Bioessays, 16: 565-76 (1994) 1994

      Show Abstract
      8086005 8086005
      PI 3-kinase: structural and functional analysis of intersubunit interactions.
      Dhand, R, et al.
      EMBO J., 13: 511-21 (1994) 1994

      Show Abstract
      8313896 8313896
      Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.
      Hiles, I D, et al.
      Cell, 70: 419-29 (1992) 1992

      Show Abstract
      1322797 1322797
      Purification and characterization of phosphoinositide 3-kinase from rat liver.
      Carpenter, C L, et al.
      J. Biol. Chem., 265: 19704-11 (1990) 1990

      Show Abstract
      2174051 2174051

      Technical Info

      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

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      Life Science Research > Antibodies and Assays > Primary Antibodies