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07-280 | Anti-PEDF Antibody

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Purified Polyclonal Antibody
      Catalogue Number07-280
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PEDF Antibody
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      ApplicationAnti-PEDF Antibody is an antibody against PEDF for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHis tagged fusion protein corresponding to full length human PEDF (Pigment Epitheliuml Derived Factor) expressed in baby hamster kidney cells
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SERPINF1
      • EPC-1
      • PEDF
      • Serpin-F1
      • PIG35
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P36955 # Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
      SIZE: 418 amino acids; 46342 Da
      SUBCELLULAR LOCATION: Secreted. Melanosome. Note=Enriched in stage I melanosomes.
      TISSUE SPECIFICITY: Retinal pigment epithelial cells and blood plasma.
      DEVELOPMENTAL STAGE: Expressed in quiescent cells.
      DOMAIN: SwissProt: P36955 The N-terminal (AA 44-121) exhibits neurite outgrowth- inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
      PTM: The N-terminus is blocked.
      SIMILARITY: Belongs to the serpin family.
      Molecular Weight50kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Y79 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PEDF (rabbit polyclonal IgG) - 2279525 2279525
      Anti-PEDF (rabbit polyclonal IgG) -2491164 2491164
      Anti-PEDF - 22153 22153
      Anti-PEDF -2526704 2526704
      Anti-PEDF -2610365 2610365
      Anti-PEDF -2622571 2622571
      Anti-PEDF -2700825 2700825
      Anti-PEDF -2707909 2707909
      Anti-PEDF -2746279 2746279


      Reference overviewApplicationPub Med ID
      Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1/2 and induction of Bcl-2.
      Sanchez, A; Tripathy, D; Yin, X; Luo, J; Martinez, J; Grammas, P
      Neuroscience research 72 1-8 2012

      Show Abstract
      Western Blotting21946416 21946416
      Multiple neurotrophic effects of VEGF on cultured neurons.
      Sanchez, A; Wadhwani, S; Grammas, P
      Neuropeptides 44 323-31 2010

      Show Abstract Full Text Article
      20430442 20430442
      Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues.
      Karakousis, P C, et al.
      Mol. Vis., 7: 154-63 (2001) 2001

      Show Abstract
      11438800 11438800

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