MABC290 Anti-PDL-1/CD274 Antibody, clone 3F2.1

MABC290
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC290
      DescriptionAnti-PDL-1/CD274 Antibody, clone 3F2.1
      Alternate Names
      • Programmed cell death 1 ligand 1
      • PD-L1
      • PDCD1 ligand 1
      • Programmed death ligand 1
      • B7 homolog 1
      • B7-H1
      • CD274
      • PDL-1
      Background InformationProgrammed cell death 1 ligand 1 (PDL-1) is a B7 related protein belonging to the BTN/MOG family. PDL-1 is essential for T-cell proliferation and production of IL10 and IFNG. PDL-1 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PDL-1 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PDL-1 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PDL-1/CD274 Antibody, clone 3F2.1 is an antibody against PDL-1/CD274 for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 and 1:500 dilution from a representative lot detected PDL-1/CD274 in human tonsil and skeletal muscle tissue, respectively.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the extracellular domain of human PDL-1/CD274.
      Epitopeextracellular domain
      Clone3F2.1
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD274
      • B7H1
      • PDCD1L1
      • PDCD1LG1
      • PDL1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~40 kDa observed. The calculated molecular weight is 33 kDa; however, this protein may be observed at higher molecular weights to due to heavy glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human skeletal muscle tissue.

      Western Blotting Analysis: 1 µg/mL of this antibody detected PDL-1/CD274 in 10 µg of human skeletal muscle tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-PDL-1/CD274 Antibody, clone 3F2.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PDL-1/CD274 Antibody, clone 3F2.1 Certificates of Analysis

      TitleLot Number
      Anti-PDL-1/CD274, clone 3F2.1 - Q2426882Q2426882
      Anti-PDL-1/CD274, clone 3F2.1 - 32434643243464
      Anti-PDL-1/CD274, clone 3F2.1 -26465012646501
      Anti-PDL-1/CD274, clone 3F2.1 -26657982665798
      Anti-PDL-1/CD274, clone 3F2.1 -27106142710614
      Anti-PDL-1/CD274, clone 3F2.1 -27766172776617
      Anti-PDL-1/CD274, clone 3F2.1 -28167242816724
      Anti-PDL-1/CD274, clone 3F2.1 Monoclonal Antibody3109274
      Anti-PDL-1/CD274, clone 3F2.1 Monoclonal Antibody3109758
      Anti-PDL-1/CD274, clone 3F2.1 Monoclonal Antibody2909630

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies