ABC324 Anti-PDL-1 Antibody

ABC324
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IH(P), IF Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABC324
      DescriptionAnti-PDL-1 Antibody
      Alternate Names
      • PDL-1 Antibody
      • PDL-1
      • Programmed cell death 1 ligand-1
      • programmed death ligand 1
      • PD-L1
      • B7-H1
      Background InformationProgrammed cell death 1 ligand 1 (PDL-1) is a B7 related protein belonging to the BTN/MOG family. PDL-1 is essential for T-cell proliferation and production of IL10 and IFNG. PDL-1 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PDL-1 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PDL-1 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Raji cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationAnti-PDL-1 Antibody is a highly specific rabbit polyclonal antibody, that targets Programmed cell death 1 ligand 1 & has been tested in western blotting, IHC (Paraffin) & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PDL-1 in human heart tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PDL-1 in human heart tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PDL-1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CD274
      • B7H1
      • PDCD1L1
      • PDCD1LG1
      • PDL1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~30 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and 1 at ~33 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected PDL-1 in 15 µg of Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies