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ABS181 | Anti-PDE4B2 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABS181
      DescriptionAnti-PDE4B2 Antibody
      Alternate Names
      • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
      • DPDE4
      • PDE32
      Background InformationPhosphodiesterase 4B2 (PDE4B2) is a member of the PDE cyclic nucleotides. PDE4B2 is thought to contain both UCR1 and UCR2 regulatory units. PDE4B2 has been associated with schizophrenia and depression and could be a promising target for autism therapies.
      Product Information
      FormatAffinity Purified
      • Rat brain membrane tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-PDE4B2 Antibody is an antibody against PDE4B2 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the N-terminus of human PDE4B2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes PDE4B2 at the N-terminus.
      Species Reactivity
      • Rat
      Species Reactivity NoteDemonstrated to react with Rat. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
      Gene Symbol
      • PDE4B
      • DPDE4
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

      CATALYTIC ACTIVITY: Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

      COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ENZYME REGULATION: Inhibited by rolipram.

      PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

      TISSUE SPECIFICITY: Expressed in brain, heart, lung and skeletal muscle.

      SEQUENCE SIMILARITIES: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
      Molecular Weight~78 kDa observed. UniProt describes 3 isoforms produced by alternative splicing: Isoform PDE4B1 at 83.3 kDa, Isoform PDE4B2 at 64.5 kDa, and Isoform PDE4B3 at 82.1 kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Rat brain membrane tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected PDE4B2 on 10 µg of Rat brain membrane tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      PDE4B2-N4B2 2480928
      PDE4B2-N4B2 - 2327008 2327008
      PDE4B2-N4B2 - NRG1897816 NRG1897816
      PDE4B2-N4B2 -2514210 2514210
      PDE4B2-N4B2 -2806079 2806079


      Reference overviewPub Med ID
      Phosphodiesterase isoform-specific expression induced by traumatic brain injury.
      Oliva, AA; Kang, Y; Furones, C; Alonso, OF; Bruno, O; Dietrich, WD; Atkins, CM
      Journal of neurochemistry 123 1019-29 2012

      Show Abstract
      23057870 23057870

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      Life Science Research > Antibodies and Assays > Primary Antibodies