ABF133 Anti-PD-L1 Antibody/CD274

ABF133
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, FC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABF133
      DescriptionAnti-PD-L1 Antibody/CD274
      Alternate Names
      • Programmed cell death 1 ligand 1
      • PD-L1
      • PDCD1 ligand 1
      • Programmed death ligand 1
      • B7 homolog 1
      • B7-H1
      • CD274
      Background InformationProgrammed cell death 1 ligand 1 (PD-L1/CD274) is a B7 related protein belonging to the BTN/MOG family. PDL-1/CD274 is essential for T-cell proliferation and production of IL10 and IFNG. PD-L1/CD274 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PD-L1/CD274 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PD-L1/CD274 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PD-L1 Antibody/CD274 is an antibody against PD-L1/CD274 for use in western blotting & flow cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected PD-L1/CD274 in 10 µg of K562 cell lysate.

      Flow Cytometry Analysis: 0.25 µg from a representative lot detected PD-L1/CD274 in 1X10E6 K562 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human PD-L1/CD274.
      EpitopeThis antibody recognizes the Ig-like C2-type domain in the extracellular domain of PD-L1/CD274.
      Concentration1 mg/mL
      HostRabbit
      SpecificityThis antibody should recognize isoforms 1 and 2 based upon immunogen design.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rhesus Macaque based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD274
      • B7H1
      • PDCD1L1
      • PDCD1LG1
      • PDL1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~55 kDa and ~33 kDa observed. Uniprot describes three isoforms at 33 kDa, 20 kDa and 21 kDa. This antibody contains 4 known glyscosylation sytes. An unglycosylated and glycosylated/membrane form may be observed at 34 kDa and 55 kDa, respectively.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected PD-L1/CD274 in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-PD-L1 Antibody/CD274 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PD-L1 Antibody/CD274 Certificates of Analysis

      TitleLot Number
      Anti-PD-L1/CD274 - Q2399142Q2399142
      Anti-PD-L1/CD274 - 32707713270771
      Anti-PD-L1/CD274 -25931782593178
      Anti-PD-L1/CD274 -26801292680129
      Anti-PD-L1/CD274 -27002672700267
      Anti-PD-L1/CD274 -27144382714438
      Anti-PD-L1/CD274 -27241762724176
      Anti-PD-L1/CD274 -28026032802603
      Anti-PD-L1/CD274 Polyclonal Antibody3120165
      Anti-PD-L1/CD274 Polyclonal Antibody3012264

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies