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MABC178 | Anti-P-Rex1 Antibody, clone 6F12

MABC178
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC178
      DescriptionAnti-P-Rex1 Antibody, clone 6F12
      Alternate Names
      • Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
      • P-Rex1
      • PtdIns(3,4,5)-dependent Rac exchanger 1
      Background InformationPhosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1protein (P-Rex1) is a guanine nucleotide exchange factor, which is predominantly expressed in the brain and leucocytes. It exchanges GDP for GTP in Rac 1, resulting in activation of Rac and its downstream signaling molecules that mediate such cellular processes as axon migration and differentiation.
      References
      Product Information
      FormatPurified
      Control
      • THP-1 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-P-Rex1, clone 6F12 is validated for use in IP, WB, IH for the detection of P-Rex1.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory to detect P-Rex 1 in PC3 cell lysate (Donald, S.,et al., 2010.), bone-marrow-derived neutrophils from mice (Qin, J., et al., 2009.), and mouse brain sections. (Welch, H, et al., 2005.)
      Biological Information
      ImmunogenLinear peptide corresponding to human P-Rex 1.
      Clone6F12
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PREX1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~186 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in THP-1 cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected P-Rex 1 in 10 µg of THP-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-P-Rex1, clone 6F12 2475089
      Anti-P-Rex1, clone 6F12 - 2061446 2061446
      Anti-P-Rex1, clone 6F12 - 2561143 2561143
      Anti-P-Rex1, clone 6F12 - Q2053122A Q2053122A
      Anti-P-Rex1, clone 6F12 -2662339 2662339

      References

      Reference overviewPub Med ID
      Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.
      Qin, J, et al.
      Oncogene, 28: 1853-63 (2009) 2009

      Show Abstract
      19305425 19305425
      P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.
      Donald, Sarah, et al.
      Proc. Natl. Acad. Sci. U.S.A., 105: 4483-8 (2008) 2008

      Show Abstract
      18334636 18334636
      P-Rex1 regulates neutrophil function.
      Welch, Heidi C E, et al.
      Curr. Biol., 15: 1867-73 (2005) 2005

      Show Abstract
      16243035 16243035

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies