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ABN1735 | Anti-Oxytocin Receptor

NewABN1735
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABN1735
      DescriptionAnti-Oxytocin Receptor
      Alternate Names
      • Oxytocin receptor
      • OT-R
      Background InformationOxytocin receptor (UniProt P97926; also known as OT-R) is encoded by the Oxtr (also known as Otr) gene (Gene ID 18430) in murine species. Oxytocin receptor (OT-R) is widely expressed in the reproductive tract, brain, kidneys, and many other organs, where it mediates the biological functions of oxytocin (OT) in mammals. Best known for their role in lactation and parturition, OT-R and OT meidate a wide variety of physiological functions, including estrous cycle, bone formation, social behaviors, as well as regulation of energy homeostasis, including food intake and thermoregulation. Central administration of OT decreases food consumption in rats, and nesfatin (a satiety hormone) increases OT secretion. Oxt-null and Oxtr-null mice display aberrant thermoregulatory function. In addition, Oxtr-knockout mice have a morphological defect in brown adipose tissue (BAT) cells and develop obesity. Human and murine oxytocin receptors are 7-transmembrane (a.a. 39-63, 75-97, 114-135, 155-175, 203-225, 275-293, 309-331) GPCRs with their N-terminal end at the extracellular side (a.a. 1-38) and C-terminal end at the cytoplasmic side (human a.a. 332-389 and mouse a.a. 332-388).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide
      Applications
      ApplicationAnti-Oxytocin Receptor Antibody, Cat. No. ABN1735, is a highly specific rabbit polyclonal antibody, that targets Oxytocin Receptor 1 and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected oxytocin receptor in 10 µg of A431, HEK293, HeLa, Jurkat, MCF-7, and Raji membrane extracts.

      Immunofluorescence Analysis: A 1:1000 dilution from a representative lot detected oxytocin receptor immunoreactivity in wild-type, but not Oxtr-knockout, mouse frozen brain tissue sections (Courtesy of Dr. Moses V. Chao, Langone Medical Center, New York University, U.S.A).
      Biological Information
      ImmunogenBSA-conjugated linear peptide corresponding to a sequence from mouse oxytocin receptor N-terminal extracellular domain.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody specifically stained wild-type, but not Oxtr-knockout, mouse brain tissue sections (Courtesy of Dr. Moses V. Chao, Langone Medical Center, New York University, U.S.A).
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteMouse, Human.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Oxtr
      • Otr
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~55-60 kDa observed. The target band size appears larger than the calculated molecular weight of 42.77/42.81 kDa (human/mouse) due to glycosylation. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human uterus.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected oxytocin receptor in 10 µg of human uterus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications