AB911 Anti-Oxytocin Antibody

AB911
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ht, M, R, Rb, Sh DB, ICC, IH(P), RIA Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB911
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Oxytocin Antibody
      References
      Product Information
      FormatSerum
      Control
      • Pituitary Gland
      PresentationNeat rabbit antisera. Liquid. Contains no preservative.
      Applications
      ApplicationAnti-Oxytocin Antibody is an antibody against Oxytocin for use in DB, IC, IH(P), RIA.
      Key Applications
      • Dot Blot
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      • Radioimmunoassay
      Application NotesImmunohistochemistry: 1:5,000-1:10,000 (18-24 hour incubation) on formalin, Bouin's or Zamboni's fixed tissue. Will react on paraffin embedded tissue.

      Immunocytochemistry: 1:10,000 on fetal rat neurons.

      Dot Blot: 1:1000

      RIA

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic oxytocin (Sigma) conjugated to thyroglobulin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Oxytocin. Less than 1% cross-reactivity with arginine vasopressin.
      Species Reactivity
      • Human
      • Hamster
      • Mouse
      • Rat
      • Rabbit
      • Sheep
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThere are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
      Gene Symbol
      • OXT
      • MGC126890
      • MGC126892
      • OT
      • OT-NPI
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01178 # Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
      SIZE: 125 amino acids; 12722 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P01178 ## Belongs to the vasopressin/oxytocin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Oxytocin Polyclonal Antibody2944904
      RABBIT ANTI-OXYTOCIN POLYCLONAL ANTIBODY - 24303282430328
      RABBIT ANTI-OXYTOCIN POLYCLONAL ANTIBODY - 24531352453135
      RABBIT ANTI-OXYTOCIN - 24920992492099
      RABBIT ANTI-OXYTOCIN -27597442759744
      RABBIT ANTI-OXYTOCIN -27888982788898
      RABBIT ANTI-OXYTOCIN POLYCLONAL ANTIBODY2907670
      RABBIT ANTI-OXYTOCIN POLYCLONAL ANTIBODY2957418
      RABBIT ANTI-OXYTOCIN POLYCLONAL ANTIBODY - 20021732002173
      RABBIT ANTI-OXYTOCIN POLYCLONAL ANTIBODY - 20707992070799

      References

      Reference overviewApplicationSpeciesPub Med ID
      Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain.
      Bean, JC; Lin, TW; Sathyamurthy, A; Liu, F; Yin, DM; Xiong, WC; Mei, L
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  13549-66  2014

      Show Abstract
      ImmunohistochemistryMouse25274830 25274830
      Paternal deprivation alters play-fighting, serum corticosterone and the expression of hypothalamic vasopressin and oxytocin in juvenile male mandarin voles.
      Jianli Wang,Fadao Tai,Xingfu Yan,Peng Yu
      Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology  198  2012

      Show Abstract
      22926316 22926316
      The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats.
      Hicks, C; Jorgensen, W; Brown, C; Fardell, J; Koehbach, J; Gruber, CW; Kassiou, M; Hunt, GE; McGregor, IS
      Journal of neuroendocrinology  24  1012-29  2012

      Show Abstract
      22420322 22420322
      DLK1 is a somato-dendritic protein expressed in hypothalamic arginine-vasopressin and oxytocin neurons.
      Villanueva, C; Jacquier, S; de Roux, N
      PloS one  7  e36134  2012

      Show Abstract
      22563444 22563444
      Effects of RFamide-Related Peptide (RFRP)-1 and RFRP-3 on Oxytocin Release and Anxiety-Related Behaviour in Rats.
      Kaewwongse M, Takayanagi Y, Onaka T.
      Journal of neuroendocrinology  23  20-7  2011

      Show Abstract
      21029217 21029217
      MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635.
      Glenn E Hunt,Iain S McGregor,Jennifer L Cornish,Paul D Callaghan
      Brain research bulletin  86  2011

      Show Abstract
      21745546 21745546
      Activation of different neuronal phenotypes in the rat brain induced by liver ischemia–reperfusion injury: dual Fos/neuropeptide immunohistochemistry.
      J Bundzikova,Z Pirnik,L Lackovicova,B Mravec,A Kiss
      Cellular and molecular neurobiology  31  2011

      Show Abstract
      21061149 21061149
      Oxytocin immunoreactivity in the corpus cavernosum of patients with erectile dysfunction.
      Fatih Tarhan,Gökhan Faydacı,Aylin Ege Gül,Uğur Kuyumcuoğlu,Bilal Eryıldırım
      Urologia internationalis  87  2011

      Show Abstract
      21832819 21832819
      Early life stress disrupts peripubertal development of aggression in male mice.
      Tsuda MC, Yamaguchi N, Ogawa S
      Neuroreport  22  259-63.  2011

      Show Abstract
      21403582 21403582
      Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry.
      A Kiss, J Bundzikova, Z Pirnik, JD Mikkelsen
      Journal of neuroscience research  88  677-85  2010

      Show Abstract
      19774673 19774673

      Data Sheet

      Title
      Anti-Oxytocin - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies