AB1774 Anti-Opioid Receptor Antibody, µ, pain

AB1774
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Gp Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1774
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Opioid Receptor Antibody, µ, pain
      Alternate Names
      • MOR-1
      References
      Product Information
      FormatSerum
      PresentationLiquid, no preservatives.
      Applications
      ApplicationAnti-Opioid Receptor Antibody, μ, pain is an antibody against Opioid Receptor for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:5,000 using a cyanine conjugated secondary antibody. Lightly fixed 4% PFA material is recommended.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide (NHQLENLEAETAPLP) corresponding to amino acids 384-398 from the carboxy-terminus of the cloned rat μ opioid receptor-1.
      HostGuinea Pig
      Specificityμ Opioid Receptor, MOR-1. The antiserum has been tested on tissue sections from the central nervous system. The staining pattern for the immunoreactive fibers obtained with the AB1774 corresponds to the pattern described using in situ hybridization with probes to rat MOR-1 mRNA. The MOR-1 immunoreactivity corresponds to what has been described for using other antibodies to MOR-1 as well as binding studies with mu receptor ligands. Preabsorption of the antiserum with the immunogen peptide completely abolishes the immunostaining.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OPRM1
      • MOR-1
      • MOR1
      • OPRM
      • KIAA0403
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35372 # Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
      SIZE: 400 amino acids; 44779 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: P35372 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      GUINEA-PIG ANTI-m OPIOID RECEPTOR-1 POLYCLONAL ANTIBODY - 19973791997379

      References

      Reference overviewApplicationPub Med ID
      Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia.
      Yang, Y; Zhang, YG; Lin, GA; Xie, HQ; Pan, HT; Huang, BQ; Liu, JD; Liu, H; Zhang, N; Li, L; Chen, JH
      PloS one  9  e89583  2014

      Show Abstract
      Immunohistochemistry24586889 24586889
      A major external source of cholinergic innervation of the striatum and nucleus accumbens originates in the brainstem.
      Dautan, D; Huerta-Ocampo, I; Witten, IB; Deisseroth, K; Bolam, JP; Gerdjikov, T; Mena-Segovia, J
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  4509-18  2014

      Show Abstract
      Immunohistochemistry24671996 24671996
      Synaptic connections between endomorphin 2-immunoreactive terminals and μ-opioid receptor-expressing neurons in the sacral parasympathetic nucleus of the rat.
      Dou, XL; Qin, RL; Qu, J; Liao, YH; Lu, Yc; Zhang, T; Shao, C; Li, YQ
      PloS one  8  e62028  2013

      Show Abstract
      Immunohistochemistry23671582 23671582
      Enhanced dendritic availability of μ-opioid receptors in inhibitory neurons of the extended amygdala in Mice deficient in the corticotropin-releasing factor-1 receptor.
      Jaferi A, Zhou P, Pickel VM
      Synapse (New York, NY)  65  8-20. doi  2011

      Show Abstract
      20506149 20506149
      Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.
      Homma, D; Sumi-Ichinose, C; Tokuoka, H; Ikemoto, K; Nomura, T; Kondo, K; Katoh, S; Ichinose, H
      The Journal of biological chemistry  286  1445-52  2011

      Show Abstract
      21062748 21062748
      Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine.
      Adam S Hamlin,Gavan P McNally,R Fred Westbrook,Peregrine B Osborne
      Neuropharmacology  56  2009

      Show Abstract
      19705550 19705550
      Developmental changes of serotonin 4(a) receptor expression in the rat pre-Bötzinger complex.
      Till Manzke,Stefan Preusse,Swen Hülsmann,Diethelm W Richter
      The Journal of comparative neurology  506  2008

      Show Abstract
      18076058 18076058
      Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor.
      Thomas N Greenwell,Sheryl Martin-Schild,Fiona M Inglis,James E Zadina
      The Journal of comparative neurology  503  2007

      Show Abstract
      17492626 17492626
      The existence of opioid receptors in the cochlea of guinea pigs.
      Nopporn Jongkamonwiwat, Pansiri Phansuwan-Pujito, Stefano O Casalotti, Andrew Forge, Hilary Dodson, Piyarat Govitrapong, Nopporn Jongkamonwiwat, Pansiri Phansuwan-Pujito, Stefano O Casalotti, Andrew Forge, Hilary Dodson, Piyarat Govitrapong
      The European journal of neuroscience  23  2701-11  2006

      Show Abstract
      16817873 16817873
      Renewal of an extinguished instrumental response: neural correlates and the role of D1 dopamine receptors.
      A S Hamlin, K E Blatchford, G P McNally
      Neuroscience  143  25-38  2006

      Show Abstract
      16949214 16949214

      Data Sheet

      Title
      GUINEA-PIG ANTI-μ OPIOID RECEPTOR-1