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05-938 | Anti-ORC6 Antibody, clone 3A4

50 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ChIP R Purified Monoclonal Antibody
      Catalogue Number05-938
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-ORC6 Antibody, clone 3A4
      Product Information
      ApplicationAnti-ORC6 Antibody, clone 3A4 is a high quality Rat Monoclonal Antibody for the detection of ORC6 & has been validated in ChIP & WB.
      Key Applications
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      Biological Information
      ImmunogenFull-length human origin recognition complex 6 (ORC6). Clone 3A4.
      Cloneclone 3A4
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
      Gene Symbol
      • ORC6L
      • ORC6
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y5N6 # Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
      SIZE: 252 amino acids; 28107 Da
      SUBUNIT: ORC is composed of six subunits. Interacts with DBF4 (By similarity).
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q9Y5N6 ## Belongs to the ORC6 family.
      Molecular Weight30kDa. A non specific protein was also detected at Mr 120kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-ORC6, clone 3A4 (rat monoclonal IgG2a) - 2003348 2003348
      Anti-ORC6, clone 3A4 - 30519 30519
      Anti-ORC6, clone 3A4 - DAM1655256 DAM1655256


      Reference overviewPub Med ID
      Impaired replication dynamics at the FRA3B common fragile site.
      Aparna Palakodeti,Isabelle Lucas,Yanwen Jiang,David J Young,Anthony A Fernald,Theodore Karrison,Michelle M Le Beau
      Human molecular genetics 19 2010

      Show Abstract Full Text Article
      19815620 19815620
      Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus.
      Ritzi, Marion, et al.
      J. Cell. Sci., 116: 3971-84 (2003) 2003

      Show Abstract
      12953058 12953058

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