A part of MilliporeSigma

MABS36 | Anti-ODC1 Antibody, clone CPTC-ODC1-2

200 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Catalogue NumberMABS36
      DescriptionAnti-ODC1 Antibody, clone CPTC-ODC1-2
      Alternate Names
      • ornithine decarboxylase 1
      • ornithine decarboxylase
      Background InformationOrnithine decarboxylase (ODC1) is the first enzyme in polyamine synthesis and is mandatory for normal growth and is increased in many types of cancers. ODC1 has been shown to suppress the fmc1 deletion in yeast and restores healthy respiratory growth. ODC1 may play a role in promoting DNA synthesis in hepatocytes.
      Product Information
      • MCF-7 cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-ODC1 Antibody, clone CPTC-ODC1-2 is validated for use in WB for the detection of ODC1.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length of recombinant protein corresponding to human ODC1.

      Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq].
      Gene Symbol
      • ODC1
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryCATALYTIC ACTIVITY: L-ornithine = putrescine + CO2.

      COFACTOR: Pyridoxal phosphate.

      ENZYME REGULATION: Inhibited by S-nitrosylation.

      PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

      SUBUNIT STRUCTURE: Homodimer.

      INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

      PTM: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.

      SEQUENCE SIMILARITIES: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
      Molecular Weight ~51 kDa observed. A band at ~100 kDa may be observed in some lysates and may be the homodimer of this protein.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MCF-7 cell lysate.

      Western Blot Analysis: 10 µg/mL of this antibody detected ODC1 on 10 µg of MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information