A part of MilliporeSigma

ABE1288 | Anti-Nur77 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, ICC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABE1288
      DescriptionAnti-Nur77 Antibody
      Alternate Names
      • Nuclear receptor subfamily 4 group A member 1
      • Early response protein NAK1
      • Nuclear hormone receptor NUR/77
      • Nur77
      • Orphan nuclear receptor HMR
      • Orphan nuclear receptor TR3
      • ST-59
      • Testicular receptor 3
      Background InformationNurr77 is an internal nuclear receptor that is expressed developmentally and in the adult in many tissues including the liver, brain and thyroid. In the liver it acts along with other transcription factors to govern liver development as well as regeneration in the adult. Nur77 also participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Nur77 is also a potent pro-apoptotic protein, particularly in the brain and heart where translocation of Nur77 into the mitochondria where it induces apoptosis. Interestingly in certain cancers Nur77 overexpression is associated with pro-oncogenic activity and regulating energy levels which promotes proliferation and survival in cancer cells.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Nur77 is an antibody against Nur77 for use in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:1,000 dilution from a representative lot detected Nur77 in HEPG2 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human Nur77.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NR4A1
      • GFRP1
      • HMR
      • NAK1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~65 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human liver tissue lysate.

      Western Blotting Analysis: 0.25 µg/mL of this antibody detected Nur77 in 10 µg of human liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information