07-144 | Anti-Numb p72/p71 Antibody

07-144
200 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number07-144
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Numb p72/p71 Antibody
      References
      Product Information
      FormatPurified
      Applications
      ApplicationThis Anti-Numb p72/p71 Antibody is validated for use in WB for the detection of Numb p72/p71.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptides, residues 377-393 and 388-404 of murine p71 Numb
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • NUMB
      • h-Numb
      • S171
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49757 # Implicated in the control of cell fate decisions during development.
      SIZE: 651 amino acids; 70804 Da
      SUBUNIT: Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.
      SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
      PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
      SIMILARITY: SwissProt: P49757 ## Contains 1 PID domain.
      Molecular Weight71-72 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from human A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-Numb p72/p71 - 20173 20173

      References

      Reference overviewPub Med ID
      Bub1-mediated adaptation of the spindle checkpoint.
      Goto GH, Mishra A, Abdulle R, Slaughter CA, Kitagawa K
      PLoS Genet  7  e1001282.  2011

      Show Abstract Full Text Article
      21298086 21298086
      Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections.
      Maryla Krajewska, Layton H Smith, Juan Rong, Xianshu Huang, Marc L Hyer, Nikolajs Zeps, Barry Iacopetta, Steven P Linke, Allen H Olson, John C Reed, Stan Krajewski, M Krajewska, LH Smith, J Rong, X Huang, ML Hyer, N Zeps, B Iacopetta, SP Linke, AH Olson, JC Reed, S Krajewski
      The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society  57  649-63  2009

      Show Abstract Full Text Article
      19289554 19289554
      Generating neuronal diversity in the Drosophila central nervous system: a view from the ganglion mother cells.
      Karcavich, Rachel E
      Dev. Dyn., 232: 609-16 (2005)  2005

      Show Abstract
      15704126 15704126
      Asymmetric cell division.
      Roegiers, Fabrice and Jan, Yuh Nung
      Curr. Opin. Cell Biol., 16: 195-205 (2004)  2004

      Show Abstract
      15196564 15196564
      Neurons from radial glia: the consequences of asymmetric inheritance.
      Fishell, Gord and Kriegstein, Arnold R
      Curr. Opin. Neurobiol., 13: 34-41 (2003)  2003

      Show Abstract
      12593980 12593980
      Numb and Numblike control cell number during vertebrate neurogenesis.
      Johnson, Jane E
      Trends Neurosci., 26: 395-6 (2003)  2003

      Show Abstract
      12900165 12900165
      Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.
      Dho, S E, et al.
      J. Biol. Chem., 274: 33097-104 (1999)  1999

      Show Abstract
      10551880 10551880

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies