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ABC50 | Anti-Noxa Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC50
      DescriptionAnti-Noxa Antibody
      Alternate Names
      • Phorbol-12-myristate-13-acetate-induced protein 1
      • PMA-induced protein 1
      • Immediate-early-response protein APR
      • Protein Noxa
      Background InformationNoxa, a BH3-only protein, is induced in response to apoptotic stimuli such as DNA damage, hypoxia, and proteasome inhibition and required for apoptosis in response to glucose stress. Noxa is constitutively expressed in proliferating hematopoietic lineage cells. The expression of Noxa involves direct activation of its promotor by p53 and studies demonstated that the blocking of endogenous Noxa induction results in the suppression of apoptosis thereby suggesting that Noxa represents a mediator of p53 dependent apoptosis.
      Product Information
      FormatAffinity Purified
      • Osteoblasts in human bone tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Noxa Antibody is an antibody against Noxa for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Noxa in neurons in normal human brain tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Noxa at the N-terminus.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes Noxa at the N-terminus.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human.
      Predicted to react with Orangutan based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PMAIP1
      • NOXA
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

      SUBUNIT STRUCTURE: Interacts with MCL1 and BAX.

      SUBCELLULAR LOCATION: Mitochondrion

      TISSUE SPECIFICITY: Highly expressed in adult T-cell leukemia cell line.

      INDUCTION: Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses.

      DOMAIN: The BH3 motif is essential for pro-apoptotic activity.

      SEQUENCE SIMILARITIES: Belongs to the PMAIP1 family.
      Molecular Weight7 kDa calculated. Possible ubiquitination may result in observed higher molecular weights (Baou, M., et al. (2010). Haematologica. 95(9):1510-1518).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in osteoblasts in human bone tissue.

      Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected Noxa in osteoblasts in human bone tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Noxa - NRG1920226 NRG1920226
      Anti-Noxa -2496222 2496222


      Reference overviewPub Med ID
      X-ray structure of the complete ABC enzyme ABCE1 from Pyrococcus abyssi.
      Annette Karcher,Alexandra Schele,Karl-Peter Hopfner
      The Journal of biological chemistry 283 2008

      Show Abstract
      18160405 18160405
      Expression profiling of ABC transporters in a drug-resistant breast cancer cell line using AmpArray.
      Yang Liu,Hui Peng,Jian-Ting Zhang
      Molecular pharmacology 68 2005

      Show Abstract
      15901850 15901850

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