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AB15514 | Anti-Neuroligin 3 Antibody

AB15514
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC, ELISA Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15514
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Neuroligin 3 Antibody
      Background InformationNeuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses.
      References
      Product Information
      FormatPurified
      PresentationLiquid in PBS with 0.1% BSA and 0.05% sodium azide
      Applications
      ApplicationThis Anti-Neuroligin 3 Antibody is validated for use in WB, IH, ELISA for the detection of Neuroligin 3.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • ELISA
      Application NotesWestern blot: 1-10 μg/mL using ECL.
      Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 μg/mL
      ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide near the C-terminus of human Neuroligin 3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityNeuroligin 3 (NLGN3)
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.
      Gene Symbol
      • NLGN3
      • HNL3
      • NL3
      • AUTSX1
      • ASPGX1
      • KIAA1480
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NZ94 # Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia- glia or glia-neuron interactions in the developing peripheral nervous system.
      SIZE: 848 amino acids; 93895 Da
      SUBUNIT: Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta (By similarity). Probably interacts through its C- terminus with DLG4/PSD-95 third PDZ domain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
      DISEASE: SwissProt: Q9NZ94 # Defects in NLGN3 may be the cause of susceptibility to X- linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. & Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.
      SIMILARITY: SwissProt: Q9NZ94 ## Belongs to the type-B carboxylesterase/lipase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NEUROLIGIN 3 -2621533 2621533
      RABBIT ANTI-NEUROLIGIN 3 -2686222 2686222
      RABBIT ANTI-NEUROLIGIN 3 -2686869 2686869
      RABBIT ANTI-NEUROLIGIN 3 -2689179 2689179
      RABBIT ANTI-NEUROLIGIN 3 -2768759 2768759
      RABBIT ANTI-NEUROLIGIN 3 -2803660 2803660
      RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY - 2019780 2019780
      RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY - 2041587 2041587
      RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY - 2197189 2197189
      RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY - 2341093 2341093

      Data Sheet

      Title
      RABBIT ANTI-NEUROLIGIN 3 AFFNITY PURIFIED POLYCLONAL ANTIBODY