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AB15580 | Anti-NeuroD 1 Antibody

AB15580
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15580
      ReplacesAB5686
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NeuroD 1 Antibody
      Alternate Names
      • Neurogenic differentiation factor 1
      References
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS with 0.1% sodium azide.
      Applications
      ApplicationDetect NeuroD 1 using this Anti-NeuroD 1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 0.5-1.0 μg/mL on mouse brain lysate.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide
      HostRabbit
      SpecificityNeuroD1 (Neurogenic differentiation factor 1). By Western blot the antibody recognizes a band at ~45 kDa on human, rat and mouse brain lysate.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
      Gene Symbol
      • NEUROD1
      • NeuroD1
      • NeuroD
      • BETA2
      • BHF-1
      • NEUROD
      • NIDDM
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13562 # Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
      SIZE: 356 amino acids; 39890 Da
      SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with TCF3/E47. Interacts with RREB1.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
      PTM: Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth (By similarity).
      DISEASE: SwissProt: Q13562 # Defects in NEUROD1 are the cause of maturity onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY [MIM:606391] is characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
      SIMILARITY: SwissProt: Q13562 ## Contains 1 basic helix-loop-helix (bHLH) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NEUROD1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2387802 2387802
      RABBIT ANTI-NEUROD1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2433548 2433548
      RABBIT ANTI-NEUROD1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2006931 2006931
      RABBIT ANTI-NEUROD1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2049228 2049228
      RABBIT ANTI-NEUROD1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2219353 2219353
      RABBIT ANTI-NEUROD1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2332547 2332547

      References | 11 Available | See All References

      Reference overviewApplicationSpeciesPub Med ID
      Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain.
      Vasistha, NA; García-Moreno, F; Arora, S; Cheung, AF; Arnold, SJ; Robertson, EJ; Molnár, Z
      Cerebral cortex (New York, N.Y. : 1991) 25 3290-302 2015

      Show Abstract
      ImmunohistochemistryMouse24927931 24927931
      A transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects.
      Filemon Dela Cruz,Melissa Terry,Igor Matushansky
      Differentiation; research in biological diversity 83 2012

      Show Abstract
      22406973 22406973
      β-2 Spectrin is involved in hepatocyte proliferation through the interaction of TGFβ/Smad and PI3K/AKT signalling.
      Zhijun Wang,Yuhu Song,Wei Tu,Xingxing He,Jusheng Lin,Fang Liu
      Liver international : official journal of the International Association for the Study of the Liver 32 2012

      Show Abstract
      22541060 22541060
      Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain.
      Kallur T, Farr TD, Böhm-Sturm P, Kokaia Z, Hoehn M
      The European journal of neuroscience 34 382-93. doi 2011

      Show Abstract
      21707793 21707793
      Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
      Gerbe, F; van Es, JH; Makrini, L; Brulin, B; Mellitzer, G; Robine, S; Romagnolo, B; Shroyer, NF; Bourgaux, JF; Pignodel, C; Clevers, H; Jay, P
      The Journal of cell biology 192 767-80 2011

      Show Abstract Full Text Article
      21383077 21383077
      Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation.
      Zhou, B; Margariti, A; Zeng, L; Habi, O; Xiao, Q; Martin, D; Wang, G; Hu, Y; Wang, X; Xu, Q
      Arteriosclerosis, thrombosis, and vascular biology 31 2676-84 2011

      Show Abstract
      21836063 21836063
      Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation.
      Hu, Q; Gao, F; Tian, W; Ruteshouser, EC; Wang, Y; Lazar, A; Stewart, J; Strong, LC; Behringer, RR; Huff, V
      The Journal of clinical investigation 121 174-83 2011

      Show Abstract
      Western Blotting21123950 21123950
      The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.
      Tsarovina, K; Reiff, T; Stubbusch, J; Kurek, D; Grosveld, FG; Parlato, R; Schütz, G; Rohrer, H
      The Journal of neuroscience : the official journal of the Society for Neuroscience 30 10833-43 2010

      Show Abstract
      20702712 20702712
      Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells.
      Leah M Wilson,Stephen H K Wong,Ningpu Yu,Elizabeth Geras-Raaka,Bruce M Raaka,Marvin C Gershengorn
      Stem cells (Dayton, Ohio) 27 2009

      Show Abstract Full Text Article
      19785038 19785038
      Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.
      Anne-Laure Cattin,Johanne Le Beyec,Frederick Barreau,Susan Saint-Just,Anne Houllier,Frank J Gonzalez,Sylvie Robine,Martine Pinçon-Raymond,Philippe Cardot,Michel Lacasa,Agnès Ribeiro
      Molecular and cellular biology 29 2009

      Show Abstract Full Text Article
      19805521 19805521

      Data Sheet

      Title
      Anti-NeuroD1 - Data Sheet