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MABN534 | Anti-Neuregulin-CRD, Type III Antibody, clone N126B/31

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC, WB M Purified Monoclonal Antibody
      Catalogue NumberMABN534
      DescriptionAnti-Neuregulin-CRD, Type III Antibody, clone N126B/31
      Alternate Names
      • Neuregulin 1
      Background InformationCysteine-rich domain (CRD), Type III belongs to the Neuregulin-1(NRG1) family of proteins, which are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (defined by the N-terminal cysteine-rich domain (CRD), also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development . Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons. Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal.
      Product Information
      • Human cardiac myocytes tissue
      PresentationPurified mouse monoclonal IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Neuregulin-CRD, Type III Antibody, clone N126B/31 is a highly specific mouse monoclonal antibody, that targets Neuregulin & has been tested in IHC & western blotting.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Neuregulin-CRD, Type III in normal human brain (frontal cortex) tissue.
      Western Blotting Analysis: A representative lot detected Neuregulin-CRD, Type III in COS cells transiently transfected with Myc-tagged Neuregulin-CRD, Type III (Prof. J. Trimmer, University of California, Davis.).
      Biological Information
      ImmunogenRecombinant protein corresponding to the N-terminus of human Neuregulin-CRD, Type III.
      Cloneclone N126B/31
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the N-terminus of Neuregulin-CRD, Type III.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Other homologies: Mouse (85% sequence homology) and Rat (82% sequence homology).
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NRG1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight31 kDa calculated. Uniprot describes multiple isoforms produced by alternative splicing, isoform 10 is only expressed in neurons. (Vartanian, T., et al. (1997). JCB. 137(1):211-220)(Montero, J. C., et al. (2000). Mole. Cell. Neuro. 16(5):631-648).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cardiac myocytes tissue.

      Imunnohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Neuregulin-CRD, Type III in human cardiac myocytes tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information