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MABN42 | Anti-Neuregulin-1 Antibody, clone D11

MABN42
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN42
      DescriptionAnti-Neuregulin-1 Antibody, clone D11
      Alternate Names
      • neuregulin 1
      • sensory and motor neuron derived factor
      • neu differentiation factor
      • pro-neuregulin-1, membrane-bound isoform
      • heregulin, alpha (45kD, ERBB2 p185-activator)
      • heregulin, alpha (45kD, ERBB2 p185-activator)
      • glial growth factor
      Background InformationThe group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003).
      References
      Product Information
      FormatPurified
      Control
      • Mouse brain microsomal tissue lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Neuregulin-1 using this Anti-Neuregulin-1 Antibody, clone D11 validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.)
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain.
      EpitopeExtracellular domain
      CloneD11
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes Neuregulin-1 at the extracellular domain.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GGF
      • NDF
      • GGF2
      • HGL
      • MST131
      • HRGA
      • HRG
      • HRG1
      • SMDF
      • ARIA
      • pro-NRG1
      • MSTP131
      • Pro-NRG1
      Purification MethodProtein G
      UniProt Number
      Molecular Weight~29 kDa observed. This target has been shown to undergo differential splicing during development into ~30 different isoforms.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse brain microsomal tissue lysate.

      Western Blot Analysis: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Neuregulin-1, clone D11 - 2189730 2189730
      Anti-Neuregulin-1, clone D11 - 2301298 2301298
      Anti-Neuregulin-1, clone D11 - NRG1848959 NRG1848959
      Anti-Neuregulin-1, clone D11 -2514193 2514193
      Anti-Neuregulin-1, clone D11 -2571289 2571289

      References

      Reference overviewPub Med ID
      Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex.
      Pirotte, D; Wislet-Gendebien, S; Cloes, JM; Rogister, B
      Molecular and cellular neurosciences 43 72-80 2010

      Show Abstract
      19781646 19781646