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MAB5260Z | Anti-Nerve Growth Factor Antibody, clone 27/21, azide free

MAB5260Z
25 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, R ELISA, NEUT M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB5260Z
      Replaces04-1119
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Nerve Growth Factor Antibody, clone 27/21, azide free
      Alternate Names
      • NGF
      • MAB5260
      References
      Product Information
      FormatPurified
      Control
      • Brain tissue
      PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with no preservatives.
      Applications
      ApplicationDetect Nerve Growth Factor using this Anti-Nerve Growth Factor Antibody, clone 27/21, azide free validated for use in ELISA, NEUT.
      Key Applications
      • ELISA
      • Neutralizing
      Application NotesThe antibody is used for the neutralization of NGF in cell culture systems. Furthermore the antibody is used to immunosympathectomy.

      Optimal working dilutions must be determined by end user.
      Biological Information
      Immunogen2.5 S form of mouse NGF.
      Clone27/21
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificitySpecifically reacts with the beta -subunit of NGF from mouse, in the 2.5S- as well as in the 7S-form.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
      Gene Symbol
      • NTF3
      • NT3
      • NGF2
      • HDNF
      • MGC129711
      • NGF-2
      • NT-3
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20783 # Seems to promotes the survival of visceral and proprioceptive sensory neurons.
      SIZE: 257 amino acids; 29355 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Brain and peripheral tissues.
      SIMILARITY: SwissProt: P20783 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 6 months at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2118022 2118022
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2140040 2140040
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2386503 2386503
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2393905 2393905
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2050270 2050270
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2063164 2063164
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2189718 2189718
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2219339 2219339
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2279224 2279224
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2279509 2279509
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2301653 2301653
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2327721 2327721
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2342875 2342875
      MOUSE ANTI-NERVE GROWTH FACTOR MONOCLONAL ANTIBODY - 2359949 2359949

      References | 11 Available | See All References

      Reference overviewPub Med ID
      p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.
      Forsyth, PA; Krishna, N; Lawn, S; Valadez, JG; Qu, X; Fenstermacher, DA; Fournier, M; Potthast, L; Chinnaiyan, P; Gibney, GT; Zeinieh, M; Barker, PA; Carter, BD; Cooper, MK; Kenchappa, RS
      The Journal of biological chemistry 289 8067-85 2014

      Show Abstract
      24519935 24519935
      Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons.
      Jakobson, M; Jakobson, M; Llano, O; Palgi, J; Arumäe, U
      Cell death & disease 4 e777 2013

      Show Abstract
      23969856 23969856
      Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons.
      Takahiro Tosaki,Hideki Kamiya,Yutaka Yasuda,Keiko Naruse,Koichi Kato,Mika Kozakae,Nobuhisa Nakamura,Taiga Shibata,Yoji Hamada,Eitaro Nakashima,Yutaka Oiso,Jiro Nakamura
      Experimental neurology 213 2008

      Show Abstract
      18675804 18675804
      Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage phi6 RNA-dependent RNA polymerase.
      Aalto, AP; Sarin, LP; van Dijk, AA; Saarma, M; Poranen, MM; Arumäe, U; Bamford, DH
      RNA (New York, N.Y.) 13 422-9 2007

      Show Abstract
      17237359 17237359
      Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis.
      Mariana Pehar, Patricia Cassina, Marcelo R Vargas, Raquel Castellanos, Liliana Viera, Joseph S Beckman, Alvaro G Estévez, Luis Barbeito
      Journal of neurochemistry 89 464-73 2004

      Show Abstract
      15056289 15056289
      Antibodies against mouse nerve growth factor interfere in vivo with the development of avian sensory and sympathetic neurones.
      Rohrer, H, et al.
      Development, 103: 545-52 (1988) 1988

      Show Abstract
      3246224 3246224
      Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.
      Korsching, S and Thoenen, H
      Proc. Natl. Acad. Sci. U.S.A., 80: 3513-6 (1983) 1983

      Show Abstract
      6407016 6407016
      Physiology of nerve growth factor.
      Thoenen, H and Barde, Y A
      Physiol. Rev., 60: 1284-335 (1980) 1980

      6159658 6159658
      Nerve growth factor: biological significance, measurement, and distribution.
      Harper, G P and Thoenen, H
      J. Neurochem., 34: 5-16 (1980) 1980

      6161212 6161212
      Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations.
      Suda, K, et al.
      Proc. Natl. Acad. Sci. U.S.A., 75: 4042-6 (1978) 1978

      Show Abstract
      279023 279023

      Data Sheet

      Title
      Anti-Nerve Growth Factor, Clone 27/21, Azide Free - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies