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MABT62 | Anti-Nectin-2/PVRL2 (CD112) Antibody, clone R2.525

50 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M Purified Monoclonal Antibody
      Catalogue NumberMABT62
      DescriptionAnti-Nectin-2/PVRL2 (CD112) Antibody, clone R2.525
      Alternate Names
      • poliovirus receptor-related 2 (herpesvirus entry mediator B)
      • poliovirus receptor related 2
      • poliovirus receptor-related protein 2
      • herpesvirus entry protein B
      • poliovirus receptor-like 2
      • nectin-2
      • Herpes virus entry mediator B
      • CD112 antigen
      • Herpesvirus entry mediator B
      • Nectin-2
      • nectin 2
      Background InformationNectin-2 is also known as poliovirus receptor-related protein 2 (PRR2 or PVRL2) or CD112. Nectin-2 is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. It is connected with the actin cytoskeleton through afadin inside the cell. Nectin-2 also seems to play an important part in shielding the heart against cardiac dysfunction in high pressure situations. Although Nectin-2 does not seem to be necessary under normal physiological circumstances, it acts autonomously of other adherens junction proteins.
      Product Information
      • Human KG1a myeloid leukemia cells
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Nectin-2/PVRL2 (CD112) using this Anti-Nectin-2/PVRL2 (CD112) Antibody, clone R2.525 validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenNIH/3T3 cells transfected with human Nectin-2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
      Gene Symbol
      • PVRL2
      • PRR2
      • PVRR2
      • HVEB
      • CD112
      • HveB
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Probable cell adhesion protein.

      SUBUNIT STRUCTURE: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICTY: Ubiquitous.

      SEQUENCE SIMILARITIES: Belongs to the nectin family.

      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight58 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in human KG1a myeloid leukemia cells.

      Flow Cytometry Analysis: 2.5 µg of this antibody detected Nectin-2/PVRL2 in human KG1a myeloid leukemia cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Nectin-2/PVRL2 (CD112), clone R2.525 - 2378052 2378052
      Anti-Nectin-2/PVRL2 (CD112), clone R2.525 - 2064769 2064769
      Anti-Nectin-2/PVRL2 (CD112), clone R2.525 - NRG1832162 NRG1832162


      Reference overviewPub Med ID
      The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule.
      Lopez, M; Aoubala, M; Jordier, F; Isnardon, D; Gomez, S; Dubreuil, P
      Blood 92 4602-11 1998

      Show Abstract
      9845526 9845526