MAB3908 | Anti-Na+/H+ Exchanger Isoform NHE8 Antibody

MAB3908
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, Rb IP, WB, ICC M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB3908
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Na+/H+ Exchanger Isoform NHE8 Antibody
      References
      Product Information
      FormatAscites
      PresentationAscites fluid. Liquid.
      Applications
      ApplicationThis Anti-Na+/H+ Exchanger Isoform NHE8 Antibody is validated for use in IP, WB, IC for the detection of Na+/H+ Exchanger Isoform NHE8.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern blot: 1:500 on rat, mouse and rabbit kidney. The antibody recognizes the ~85 kDa NHE8 protein.

      Immunocytochemistry on rat kidney.

      Immunoprecipitation on rat, mouse and rabbit kidney.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant human NHE8.
      HostMouse
      SpecificityNa+/H+ exchanger, isoform NHE8.
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC9A8
      • FLJ42500
      • +H
      • MGC138418
      • NHE8
      • DKFZp686C03237
      • NHE-8
      • KIAA0939
      • Na
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y2E8 # Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
      SIZE: 577 amino acids; 64976 Da
      SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Ubiquitous. Strongly expressed in skeletal muscle and kidney.
      SIMILARITY: SwissProt: Q9Y2E8 ## Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI- Na+/H+ EXCHANGER ISOFORM NHE8 MONOCLONAL ANTIBODY - 2140046 2140046
      MOUSE ANTI- Na+/H+ EXCHANGER ISOFORM NHE8 MONOCLONAL ANTIBODY 2485710
      MOUSE ANTI- Na+/H+ EXCHANGER ISOFORM NHE8 MONOCLONAL ANTIBODY - 1999452 1999452

      References

      Reference overviewPub Med ID
      Decreased NHE8 isoform expression and defective acidification in proximal convoluted tubules of senile rats.
      Mariana Fiori, Eduardo García Gras, Carlos Amorena, Mariana Fiori, Eduardo García Gras, Carlos Amorena
      Age (Dordrecht, Netherlands)  31  77-84  2009

      Show Abstract Full Text Article
      19234771 19234771

      Data Sheet

      Title
      Anti-Na+/H+ Exchanger Isoform NHE8 - Data Sheet