MAB3138 | Anti-Na+/H+ Exchanger-3 Antibody, isoform NHE3, clone 19F5

MAB3138
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, Rb ICC, IH(P), IP, WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB3138
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Na+/H+ Exchanger-3 Antibody, isoform NHE3, clone 19F5
      Alternate Names
      • NHE3
      References
      Product Information
      FormatPurified
      PresentationLiquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
      Applications
      ApplicationDetect Na+/H+ Exchanger-3 using this Anti-Na+/H+ Exchanger-3 Antibody, isoform NHE3, clone 19F5 validated for use in IC, IH(P), IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoblotting (rabbit 80 kDa and rat ~83 kDa)

      Immunohistochemistry (rat) on PLP or paraformaldehyde fixed tissue. Works on paraffin embedded tissue sections.

      Immunocytochemistry

      Immunoprecipitation (use non-ionic detergent)

      Optimal working dilutions must be determined by the user.
      Biological Information
      ImmunogenMaltose Binding Protein fusion protein containing C-terminal 131 amino acids of rabbit NHE3.
      Epitopeisoform NHE3
      Clone19F5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityNa+/H+ exchanger, isoform NHE3.
      IsotypeIgG1
      Species Reactivity
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC9A3
      • NHE3
      • NHE-3
      • MGC126718
      • Na
      • MGC126720
      • +H
      UniProt Number
      UniProt SummaryFUNCTION: IInvolved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
      SIZE: 832 amino acids; 92,749 Da
      SUBUNIT: Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      PTM: Phosphorylated by PKA, which inhibits activity (By similarity).
      SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2383979 2383979
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2187376 2187376
      Na+/H+ EXCHANGER ISOFORM NHE3- 2512342 2512342

      References

      Reference overviewPub Med ID
      Effect of chronic inhibition of converting enzyme on proximal tubule acidification.
      Diaz-Sylvester, PL; Fiori, MC; Dieguez, SM; Müller, AC; Lopardo, ML; Amorena, CE
      American journal of physiology. Regulatory, integrative and comparative physiology  294  R2014-20  2008

      Show Abstract
      18401002 18401002
      In vitro and in vivo evaluation of proximal tubular acidification in aging rats.
      M Mac Laughlin, M C Damasco, P Igarreta, C Amorena
      American journal of physiology. Regulatory, integrative and comparative physiology  280  R1627-31  2001

      Show Abstract
      11353664 11353664
      Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney.
      Biemesderfer, D, et al.
      Am. J. Physiol., 273: F289-99 (1997)  1997

      9277590 9277590

      Data Sheet

      Title
      Anti-Na+/H+ Exchanger-3, isoform NHE3, clone 19F5 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies