A part of MilliporeSigma

ABN1001 | Anti-NPL4 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABN1001
      DescriptionAnti-NPL4 Antibody
      Alternate Names
      • NPL4
      • Nuclear protein localization protein 4 homolog
      Background InformationNPL4 is one of a three-protein complex that binds ubiquitinated proteins, and it is necessary for the export of misfolded proteins from the ER to the cytoplasm where they are degraded by the proteasome. The NPL4 complex also is critical for spindle disassembly at the end of mitosis. NPL4 was originally identified as a nuclear pore localization protein, and it is necessary for the formation of a close nuclear envelope. NPL4 interacts with UFD1L (ubiquitin fusion degradation protein 1 homolog) which then binds the ATPase protein VCP, also known as valosin-containing protein. Recent research demonstrates that NPL4 also forms additional complexes with other proteins such as I-kappa, B, alpha the inhibitor of NF-kappa B family of transcription factors.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-NPL4 Antibody is an antibody against NPL4 for use in Immunohistochemistry and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected NPL4 in human cerebral cortex, human kidney, human thalamus, and human cerebellum tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NPL4 near the N-terminal.
      EpitopeNear N-terminal
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Mouse, Rat, Horse, Yeast, Hamster based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NPLOC4
      • KIAA1499
      • NPL4
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~72 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human fetal liver tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected NPL4 in 10 µg of human fetal liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information