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AB5403 | Anti-NMDAR2B Antibody, phosphoTyr 1472

AB5403
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5403
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR2B Antibody, phosphoTyr 1472
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 μg/mL BSA, 50% glycerol and 0.09% sodium azide.
      Applications
      ApplicationAnti-NMDAR2B Antibody, phosphoTyr 1472 is an antibody against NMDAR2B for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids surrounding the phosphoTyr1472 of rat NMDAR2B.
      EpitopephosphoTyr 1472
      HostRabbit
      SpecificityNMDAR2B, phosphoTyr1472. The antibody recognizes a protein of ~180 kDa in Western blot. The labeling of the NMDAR2B protein in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. Two additional lower molecular weight bands are present in Western blots of rat brain.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
      Gene Symbol
      • GRIN2B
      • MGC142180
      • Glutamate
      • NR2B
      • NMDAR2B
      • NR3
      • MGC142178
      • hNR3
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
      SIZE: 1484 amino acids; 166367 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
      SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NMDAR2B phosphoTyr1472 2465125
      RABBIT ANTI-NMDAR2B phosphoTyr1472 2479978
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2395669 2395669
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2433286 2433286
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2019764 2019764
      RABBIT ANTI-NMDAR2B phosphoTyr1472 - 2519274 2519274
      RABBIT ANTI-NMDAR2B phosphoTyr1472 -2698392 2698392
      RABBIT ANTI-NMDAR2B phosphoTyr1472 -2736727 2736727
      RABBIT ANTI-NMDAR2B phosphoTyr1472 -2793668 2793668
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY -
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2005912 2005912
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2038248 2038248
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2051844 2051844
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2073575 2073575
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2181244 2181244
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2219291 2219291
      RABBIT ANTI-NMDAR2B phosphoTyr1472, AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2828621

      References

      Reference overviewPub Med ID
      A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
      Ferrier, J; Bayet-Robert, M; Pereira, B; Daulhac, L; Eschalier, A; Pezet, D; Moulinoux, JP; Balayssac, D
      PloS one 8 e77828 2013

      Show Abstract
      24204988 24204988
      cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.
      Hong-Bin Yang,Xian Yang,Jing Cao,Shuai Li,Yan-Ni Liu,Zhan-Wei Suo,Hong-Bin Cui,Zhong Guo,Xiao-Dong Hu
      Journal of neurochemistry 116 2011

      Show Abstract
      21054385 21054385

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

      Data Sheet

      Title
      RABBIT ANTI-NMDAR2B phosphoTyr1472 AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies