AB1555 Anti-NMDAR2A Antibody

AB1555
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, F IP, WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1555
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR2A Antibody
      References
      Product Information
      FormatSerum
      Control
      • NMDAR2A is present in high concentrations in the hippocampus
      PresentationRabbit antiserum. Liquid, no preservatives.
      Applications
      ApplicationThis Anti-NMDAR2A Antibody is validated for use in IP, WB for the detection of NMDAR2A.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Applications Not Recommended
      • Immunohistochemistry
      Application NotesWestern blotting*: 1:1,000-1:5,000 for ECL. If using labled protein-A for detection: 1:200.

      * See suggested protocol

      Immunoprecipitation using solubilized hippocampal slices. 3μL will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200μg rat brain.

      Not suggested for use in immunohistochemistry.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenC-Terminal Fusion Protein of the NMDAR2A (30 kDa), aa 1253-1391.
      HostRabbit
      SpecificityNMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Fish
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
      Gene Symbol
      • GRIN2A
      • hNR2A
      • Glutamate
      • NMDAR2A
      • NR2A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12879 # NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
      SIZE: 1464 amino acids; 165283 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: Q12879 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY - 21104752110475
      RABBIT ANTI-NMDAR2A - 24920962492096
      RABBIT ANTI-NMDAR2A -28179842817984
      RABBIT ANTI-NMDAR2A -28847122884712
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY3011419
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY3064878
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY3082830
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY2947410
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY3001095
      RABBIT ANTI-NMDAR2A POLYCLONAL ANTIBODY3028349

      References

      Reference overviewApplicationSpeciesPub Med ID
      Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.
      Portugal, GS; Al-Hasani, R; Fakira, AK; Gonzalez-Romero, JL; Melyan, Z; McCall, JG; Bruchas, MR; Morón, JA
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  527-38  2014

      Show Abstract
      Western Blotting24403152 24403152
      Cross-modal plasticity results in increased inhibition in primary auditory cortical areas.
      Mao, YT; Pallas, SL
      Neural plasticity  2013  530651  2013

      Show Abstract
      24288625 24288625
      Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine.
      Savignac, HM; Corona, G; Mills, H; Chen, L; Spencer, JP; Tzortzis, G; Burnet, PW
      Neurochemistry international  63  756-64  2013

      Show Abstract
      Western Blotting24140431 24140431
      Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity.
      Almonte, AG; Qadri, LH; Sultan, FA; Watson, JA; Mount, DJ; Rumbaugh, G; Sweatt, JD
      Journal of neurochemistry  124  109-22  2013

      Show Abstract
      23113835 23113835
      Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration.
      Abrahao, KP; Ariwodola, OJ; Butler, TR; Rau, AR; Skelly, MJ; Carter, E; Alexander, NP; McCool, BA; Souza-Formigoni, ML; Weiner, JL
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  4834-42  2013

      Show Abstract
      Western Blotting23486954 23486954
      Genetic deletion of NR3A accelerates glutamatergic synapse maturation.
      Henson, MA; Larsen, RS; Lawson, SN; Pérez-Otaño, I; Nakanishi, N; Lipton, SA; Philpot, BD
      PloS one  7  e42327  2012

      Show Abstract
      Western Blotting22870318 22870318
      Long-term consequences of a prolonged febrile seizure in a dual pathology model.
      Gibbs S, Chattopadhyaya B, Desgent S, Awad PN, Clerk-Lamalice O, Levesque M, Vianna RM, Rébillard RM, Delsemme AA, Hébert D, Tremblay L, Lepage M, Descarries L, Di Cristo G, Carmant L
      Neurobiol Dis  2011

      Show Abstract
      21406232 21406232
      N-methyl-d-aspartate, hyperpolarization-activated cation current (I) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus.
      Ouardouz M, Lema P, Awad PN, Di Cristo G, Carmant L
      The European journal of neuroscience  31  1252-60. Epub 2010 Mar 22.  2010

      Show Abstract
      20345922 20345922
      Visual experience-independent functional expression of NMDA receptors in the developing rabbit retina.
      Chang, YC; Chen, CY; Chiao, CC
      Investigative ophthalmology & visual science  51  2744-54  2010

      Show Abstract
      Immunohistochemistry20042649 20042649
      Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death.
      H-M Yu, J Xu, C Li, C Zhou, F Zhang, D Han, G-Y Zhang, H-M Yu, J Xu, C Li, C Zhou, F Zhang, D Han, G-Y Zhang
      Neuroscience  155  1120-32  2008

      Show Abstract
      18676085 18676085

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

      Data Sheet

      Title
      Anti-NMDAR2A - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies