A part of MilliporeSigma

MAB3878 | Anti-MyoD1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, H, M, R ICC, IHC, IP, WB M Purified Monoclonal Antibody
      Catalogue NumberMAB3878
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MyoD1 Antibody
      Product Information
      • Fetal Muscle, Rhabdomyosarcoma
      PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
      ApplicationAnti-MyoD1 Antibody is a high quality Mouse Monoclonal Antibody for the detection of MyoD1 & has been validated in ICC, IHC, IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1 μg/mL. Reacts with the ~45 kD protein.

      Immunohistochemistry on frozen and formalin-fixed, paraffin embedded tissue: 2-4 μg/mL.


      Immunoprecipitation: 2 μg/mg of protein lysate

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from mouse MyoD1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes MyoD1. The epitope is localized to amino acids 3-56 in the N-terminus of mouse MyoD1 protein.
      Species Reactivity
      • Chicken
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.
      Gene Symbol
      • MYOD1
      • MYOD
      • PUM
      • Myf-3
      • MYF3
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15172 # Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
      SIZE: 319 amino acids; 34490 Da
      SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.
      PTM: Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity). & Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
      SIMILARITY: SwissProt: P15172 ## Contains 1 basic helix-loop-helix (bHLH) domain.
      Molecular Weight~ 45 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-MyoD1 -2800059 2800059
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY - 2115908 2115908
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY - 2120952 2120952
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY - 2147018 2147018
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY - 2387779 2387779
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY - 2266472 2266472
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY -2583424 2583424
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY -2659265 2659265
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY -2689156 2689156
      MOUSE ANTI-MyoD1 MONOCLONAL ANTIBODY -2767268 2767268


      Reference overviewApplicationPub Med ID
      A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
      Kohsaka, S; Shukla, N; Ameur, N; Ito, T; Ng, CK; Wang, L; Lim, D; Marchetti, A; Viale, A; Pirun, M; Socci, ND; Qin, LX; Sciot, R; Bridge, J; Singer, S; Meyers, P; Wexler, LH; Barr, FG; Dogan, S; Fletcher, JA; Reis-Filho, JS; Ladanyi, M
      Nature genetics 46 595-600 2014

      Show Abstract
      24793135 24793135
      In situ mechanotransduction via vinculin regulates stem cell differentiation.
      Holle, AW; Tang, X; Vijayraghavan, D; Vincent, LG; Fuhrmann, A; Choi, YS; del Álamo, JC; Engler, AJ
      Stem cells (Dayton, Ohio) 31 2467-77 2013

      Show Abstract
      Immunocytochemistry23897765 23897765
      Prenatal and early postnatal exposure to high-saturated-fat diet represses Wnt signaling and myogenic genes in offspring rats.
      Ke-Feng Yang,Xiu-Hua Shen,Wei Cai
      Experimental biology and medicine (Maywood, N.J.) 237 2012

      Show Abstract
      22875341 22875341

      Data Sheet

      MOUSE ANTI-MyoD1

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