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MABT414 | Anti-Moesin Antibody, clone 38/87

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, B WB, FC, IP, IHC M Purified Monoclonal Antibody
      Catalogue NumberMABT414
      DescriptionAnti-Moesin Antibody, clone 38/87
      Alternate Names
      • Moesin
      • Membrane-organizing extension spike protein
      Background InformationMoesin (membrane-organizing extension spike protein) is the protein encoded by the MSN gene. Moesin is a member of the ERM (ezrin, moesin, radixin) family of proteins that regulate linkage between the plasma membrane and the actin cytoskeleton. Thus, moesin is a peripheral membrane protein that is keenly involved in the signaling and structural connections in cytoskeletal plasma membrane structures like microvilli. Moesin in its active, phosphorylated state strongly binds actin and helps anchor it to the plasma membrane. Moesin is localized to filopodia and other membranous extensions of various cell types and thus plays a role in cell-cell recognition signaling, cell movement, and cell transport. In its inactive, non-phosphorylated state, Moesin binds itself in a head-tail fashion and is incapable of binding actin or other cytoskeletal proteins. The kinase ROCK2 is central to the opening up of moesin and allowing its interaction with actin and the plasma membrane.
      Product Information
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Moesin using this mouse monoclonal antibody, Anti-Moesin Antibody, clone 38/87 validated for use in western blotting, Flow Cytometry, IP & IHC.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:2,000 dilution from a representative lot detected Moesin in 10 µg of HL-60 cell lysate.

      Flow Cytometry Analysis: 4 µg from a representative lot detected Moesin in 1X10E6 HeLa cells.

      Flow Cytometry Analysis: A representative lot from an independent laboratory detected Moesin in THP-1, U937, and MOLT-4 cells (Takamatsu, H., et al. (2009). J Immunol. 182(1):703-710.).

      Western Blotting Analysis: A representative lot from an independent laboratory detected Moesin in purified heparain-binding proteins, and from human renal cortex tisssue (Lankes, W., et al. (1988). Biochem J. 251(3):831-842.).

      Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Moesin in HT-29 cell lysate (Lankes, W., et al. (1988). Biochem J. 251(3):831-842.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Moesin in certain human brain tissues (Johnson, M. W., et al. (2002). Acta Neuropathol. 104(2):188-196.).
      Biological Information
      ImmunogenRecombinant protein corresponding to bovine Moesin.
      Species Reactivity
      • Human
      • Bovine
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MSN
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~78 kDa observed. This protein has been observed at ~78 kDa due to post-translational modification (Lankes, W., et al. (1988). Biochem J. 251(3):831-842.).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HL-60 cell lysate.

      Western Blotting Analysis: A 1:2,000 dilution from a representative lot detected Moesin in 10 µg of HL-60 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Moesin, clone 38/87 - Q2296670 Q2296670


      Reference overviewPub Med ID
      Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma.
      Takamatsu, Hiroyuki, et al.
      J. Immunol., 182: 703-10 (2009) 2009

      Show Abstract
      19109204 19109204
      Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers.
      Johnson, Michael W, et al.
      Acta Neuropathol., 104: 188-96 (2002) 2002

      Show Abstract
      12111362 12111362
      A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation.
      Lankes, W, et al.
      Biochem. J., 251: 831-42 (1988) 1988

      Show Abstract
      3046603 3046603