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ABC41 | Anti-Mitofusin-1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC41
      DescriptionAnti-Mitofusin-1 Antibody
      Alternate Names
      • Fzo homolog
      • Transmembrane GTPase MFN1, Mitofusion-1
      Background InformationAlong with Mitofusin-2 (Mfn2), Mitofusin-1 (Mfn1) is a known protein mediator of mitochondrial fusion. Mitochondrial fusion regulates mitochondrial morphogensis and supports complementation between mitochondrial genomes in mammalian cells. Two Mfn1 transcripts are detected at similar levels in a variety of human tissues and are dramatically elevated in the heart. Human Mfn1 is known to be localized in the mitochondria. It is reported that point mutations in the conserved G1 and G2 region of the Mfn1 GTPase domain result in decreased formation and fragmentation of the mitochondria, respectively.
      Product Information
      FormatAffinity Purified
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Mitofusin-1 using this Anti-Mitofusin-1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-1.
      EpitopeCytoplasmic Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes Mitofusin-1 at the cytoplasmic domain.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
      Gene Symbol
      • MFN1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.

      SUBUNIT STRUCTURE: Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion By similarity. Participates in a high molecular weight multiprotein complex.

      SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein. Isoform 2: Cytoplasm.
      Molecular Weight~86 kDa observed.
      Three isoforms of Mitofusin-1 are produced by alternative splicing with molecular weights of ~42 kDa, ~71 kDa, and ~84 kDa. Uncharacterized bands may appear at ~45 kDa, ~48 kDa, and ~55 kDa in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusin-1 in 10 µg HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Mitofusin-1 2476945
      Anti-Mitofusin-1 - 2118979 2118979
      Anti-Mitofusin-1 - 2382640 2382640
      Anti-Mitofusin-1 - 2007348 2007348
      Anti-Mitofusin-1 - 2168297 2168297
      Anti-Mitofusin-1 - 2246832 2246832
      Anti-Mitofusin-1 - 2301289 2301289
      Anti-Mitofusin-1 - NRG1903977 NRG1903977
      Anti-Mitofusin-1 -2550934 2550934
      Anti-Mitofusin-1 -2702128 2702128
      Anti-Mitofusin-1 -2798358 2798358


      Reference overviewPub Med ID
      Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens.
      Chauss, D; Basu, S; Rajakaruna, S; Ma, Z; Gau, V; Anastas, S; Brennan, LA; Hejtmancik, JF; Menko, AS; Kantorow, M
      G3 (Bethesda, Md.) 4 1515-27 2014

      Show Abstract
      24928582 24928582
      Hypoxia induced upregulation and function of the thiamine transporter, SLC19A3 in a breast cancer cell line.
      Rebecca Sweet,Amber Paul,Jason Zastre
      Cancer biology & therapy 10 2010

      Show Abstract
      20930543 20930543

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      Life Science Research > Antibodies and Assays > Primary Antibodies