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NA26 | Anti-MSH2 (Ab-1) Mouse mAb (GB12)

NA26
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H M Monoclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      NA26-100UG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 100 μg
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          Description
          OverviewRecognizes the ~100 kDa MSH2 protein in HCT116 and SW480 cells and colon tissue.
          Catalogue NumberNA26
          Brand Family Calbiochem®
          SynonymsAnti-Mismatch Repair Protein 2
          References
          ReferencesBronner, C. E., et al. 1994. Nature 368, 258.
          Papadopoulos, N., et al. 1994. Science 263, 1625.
          Peltomäki, P. T. 1994. Annals of Medicine 26, 215.
          Fishel, R., et al. 1993. Cell 75, 1027-1038, 1993.
          Leach, F. S., et al. 1993. Cell 75, 1215.
          Lindbolm, A., et al. 1993. Nature Genetics 5, 279.
          Product Information
          FormLiquid
          FormulationIn 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
          Negative controlLoVo cells
          Positive controlHCT116 or SW480 cells or colon tissue
          Preservative≤0.1% sodium azide
          Applications
          Key Applications Frozen Sections
          Immunoblotting (Western Blotting)
          Immunoprecipitation
          Paraffin Sections
          Application NotesFrozen Sections (5 µg/ml)
          Immunoblotting (1 µg/ml)
          Immunoprecipitation (1 µg/reaction)
          Paraffin Sections (3 µg/ml, heat pre-treatment required)
          Application CommentsFor paraffin sections, pre-treat with heat for 20 min. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogenan N-terminal fragment of human MSH2
          ImmunogenHuman
          CloneGB12
          HostMouse
          IsotypeIgG₁
          Species Reactivity
          • Human
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Yes
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          NA26

          References

          Reference overview
          Bronner, C. E., et al. 1994. Nature 368, 258.
          Papadopoulos, N., et al. 1994. Science 263, 1625.
          Peltomäki, P. T. 1994. Annals of Medicine 26, 215.
          Fishel, R., et al. 1993. Cell 75, 1027-1038, 1993.
          Leach, F. S., et al. 1993. Cell 75, 1215.
          Lindbolm, A., et al. 1993. Nature Genetics 5, 279.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-September-2007 RFH
          SynonymsAnti-Mismatch Repair Protein 2
          ApplicationFrozen Sections (5 µg/ml)
          Immunoblotting (1 µg/ml)
          Immunoprecipitation (1 µg/reaction)
          Paraffin Sections (3 µg/ml, heat pre-treatment required)
          DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with SP20 mouse myeloma cells. Recognizes the ~100 kDa MSH2 protein.
          BackgroundThe MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma, while germline MSH2 mutations are responsible for ~50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids.
          HostMouse
          Immunogen speciesHuman
          Immunogenan N-terminal fragment of human MSH2
          CloneGB12
          IsotypeIgG₁
          Specieshuman, not mouse
          Positive controlHCT116 or SW480 cells or colon tissue
          Negative controlLoVo cells
          FormLiquid
          FormulationIn 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsFor paraffin sections, pre-treat with heat for 20 min. Antibody should be titrated for optimal results in individual systems.
          Storage +2°C to +8°C
          Do Not Freeze Yes
          Toxicity Standard Handling
          ReferencesBronner, C. E., et al. 1994. Nature 368, 258.
          Papadopoulos, N., et al. 1994. Science 263, 1625.
          Peltomäki, P. T. 1994. Annals of Medicine 26, 215.
          Fishel, R., et al. 1993. Cell 75, 1027-1038, 1993.
          Leach, F. S., et al. 1993. Cell 75, 1215.
          Lindbolm, A., et al. 1993. Nature Genetics 5, 279.