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MABC1184 | Anti-MS4A8B Antibody, clone 3E6

100 μg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M Purified Monoclonal Antibody
      Catalogue NumberMABC1184
      DescriptionAnti-MS4A8B Antibody, clone 3E6
      Alternate Names
      • Membrane-spanning 4-domains subfamily A member 8
      • Four-span transmembrane protein 4
      • Membrane-spanning 4-domains subfamily A member 8B
      Background InformationMembrane-spanning 4-domains subfamily A member 8 (UniProt Q9BY19; also known as Four-span transmembrane protein 4, Membrane-spanning 4-domains subfamily A member 8B) is encoded by the MS4A8 (also known as 4SPAN4, CD20L5, MS4A8B) gene (Gene ID 83661) in human. Human MS4A8B and its murine Ms4a8a ortholog belong to the family of genes coding for the 4-transmembrane MS4A proteins that likely mediate cellular signaling by acting as cell-surface signaling molecules and intracellular adapter proteins, although their exact functions remain to be characterized. MS4A8B is found expressed in lung and trachea, as well as in colonic epithelial cells committed to differentiation outside the colonic crypt, but not in human colon carcinoma. Human MS4A8B and murine Ms4a8a proteins are reported to support the maintenance of a physiological barrier function in the gut by modulating the transcriptome and by conferring an increased resistance to reactive oxygen species. Ms4a8a overexpressed in a colon carcinoma cell line is shown to inhibit cancer cell proliferation and migration. Human MS4A8B protein consists of four transmembrane domains (a.a. 75-95, 99-119, 137-157, 181-201), having both its N- and C-terminal ends exposed intracellularly (a.a. 1-74 & 202-250).
      Product Information
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-MS4A8 AntibodyB, clone 3E6 is an antibody against MS4A8 for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1.0 µg of this antibody detected MS4A8B on the surface of NCI-H69 human lung carcinoma cells and LNCaP human prostate adenocarcinoma cells (Courtesy of Dr. Julie Deans, University of Calgary, Alberta, Canada).
      Biological Information
      Immunogen300-19 murine pre-B cells expressing transfected human MS4A8B GFP fusion.
      EpitopeExtracellular domain.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityClone 3E6 recognizes an extracellular epitope.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MS4A8
      • 4SPAN4
      • CD20L5
      • MS4A8B
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight26.29 kDa calculated.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in LNCaP human prostate adenocarcinoma cells.

      Flow Cytometry Analysis: 1.0 µg of this antibody detected MS4A8B on the surface of one million LNCaP human prostate adenocarcinoma cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information