A part of MilliporeSigma

MAB13489 | Anti-MMP-2 Antibody, clone 1E4.2

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, WB M Purified Monoclonal Antibody
      Catalogue NumberMAB13489
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MMP-2 Antibody, clone 1E4.2
      Alternate Names
      • Gelatinase A
      • 72 kDa Type IV Collagenase
      Product Information
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.01% sodium azide.
      ApplicationAnti-MMP-2 Antibody, clone 1E4.2 detects level of MMP-2 & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1:200- 1:1000 Immunocytochemistry: Not Tested ELISA: 1:200-1:1000 Immunohistochemistry: Not Tested Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified Human MMP-2 (Gelatinase A)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityHuman MMP-2 pro and active forms.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome.
      Gene Symbol
      • MMP2
      • TBE-1
      • CLG4A
      • CLG4
      • MMP-II
      • MONA
      • MMP-2
      • EC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08253 # In addition to gelatin and collagens, it cleaves KiSS1 at a Gly- -Leu bond.
      COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.
      SIZE: 660 amino acids; 73882 Da
      SUBUNIT: Ligand for integrin alpha-V/beta-3.
      TISSUE SPECIFICITY: Produced by normal skin fibroblasts.
      DOMAIN: SwissProt: P08253 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      PTM: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT- MMP3).
      DISEASE: SwissProt: P08253 # Defects in MMP2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA) [MIM:605156]. Inherited osteolyses or 'vanishing bone' syndromes are rare disorders of unknown etiology characterized by destruction and resorption of affected bones. MONA is an autosomal recessive osteolysis with multicentric involvement characterized by carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar subcutaneous nodules and distinctive facies. & Defects in MMP2 are the cause of Winchester syndrome [MIM:277950]. Winchester syndrome is an autosomal recessive osteolysis syndrome. Winchester syndrome is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes. The clinical and molecular findings suggest that Winchester syndrome and MONA are allelic disorders that form a continuous clinical spectrum.
      SIMILARITY: Belongs to the peptidase M10A family. & Contains 3 fibronectin type-II domains. & Contains 4 hemopexin-like domains.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 6/12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-MMP-2 (Gelatinase A) MONOCLONAL ANTIBODY - 2398150 2398150
      MOUSE ANTI-MMP-2 -2526500 2526500


      Reference overviewPub Med ID
      Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome.
      Dean, RA; Overall, CM
      Molecular & cellular proteomics : MCP 6 611-23 2007

      Show Abstract
      17200105 17200105
      Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis.
      Dean, RA; Butler, GS; Hamma-Kourbali, Y; Delbé, J; Brigstock, DR; Courty, J; Overall, CM
      Molecular and cellular biology 27 8454-65 2007

      Show Abstract Full Text Article
      17908800 17908800

      Data Sheet


      Related Products & Applications

      Related Products

      Catalog Number Description  
      04-1048 Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal Show Pricing & Availability
      AB19015 Anti-MMP-2 Antibody, catalytic domain Show Pricing & Availability
      AB19167 Anti-MMP-2 Antibody, whole molecule Show Pricing & Availability
      AB6003 Anti-MMP-2 Antibody, hinge region Show Pricing & Availability
      MAB13405 Anti-MMP-2 Proform Antibody, NT, clone CA-4001 Show Pricing & Availability
      MAB13406 Anti-MMP-2 Antibody, pro and active form, clone VB3 Show Pricing & Availability
      MAB13431 Anti-MMP-2 Antibody, pro and active form, clone A-Gel VC2 Show Pricing & Availability
      MAB13434 Anti-MMP-2 Antibody, NT, clone 5C6.2 Show Pricing & Availability
      MAB13435 Anti-MMP-2 Antibody, clone 7F3.2 Show Pricing & Availability
      MAB3308 Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11 Show Pricing & Availability

      Alternative Packsize

      Catalog Number Description  
      MAB13489-KC Anti-MMP-2 Antibody, clone 1E4.2 (KC) Show Pricing & Availability

      View Gene Related Products for this Target


      Life Science Research > Antibodies and Assays > Primary Antibodies