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ABN165 | Anti-MMEL1 Antibody

ABN165
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IHC, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABN165
      DescriptionAnti-MMEL1 Antibody
      Alternate Names
      • Membrane metallo-endopeptidase-like 1
      • Membrane metallo-endopeptidase-like 2
      • NEP2(m)
      • Neprilysin II
      • NEPII
      • Neprilysin-2
      • NEP2
      • NL2
      • Membrane metallo-endopeptidase-like 1, soluble form
      • Neprilysin-2 secreted
      • NEP2(s)
      Background InformationMembrane metallo-endopeptidase-like 1 (MMEL1) is a single-pass type II membrane protein belonging to the peptidase M13 family. MMEL1 plays an important role in pain perception, arterial pressure regulation, phosphate metabolism, and homeostasis. MMEL1 is predominantly expressed in testis and weakly expressed in brain, kidney and heart. Mutations of MMEL1 have been associated with primary biliary cirrhosis.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse testis tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-MMEL1 Antibody is validated for use in 0 for the detection of MMEL1.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:500-1,500 dilution from a representative lot detected MMEL1 in human testis and rat testis tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the lumenal topological domain of human MMEL1.
      EpitopeLumenal topological domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the lumenal topological domain of MMEL1.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MMEL1
      • MELL1
      • MMEL2
      • NEP2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~90 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing at ~89 kDa, ~69 kDa, and ~71 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse testis tissue lysate.

      Western Blot Analysis: 1.0 µg/mL of this antibody detected MMEL1 in 10 µg of mouse testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies