A part of MilliporeSigma

MABN614 | Anti-MESD Antibody, clone N88/12C

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M WB, IHC M Purified Monoclonal Antibody
      Catalogue NumberMABN614
      DescriptionAnti-MESD Antibody, clone N88/12C
      Alternate Names
      • LDLR chaperone MESD
      • Mesoderm development candidate 2
      • Mesoderm development protein
      • MESD
      Background InformationLDLR chaperone MESD, also known as Mesoderm development protein and Mesoderm development candidate 2 (Mesdc2), assists in the folding of beta-propeller/EGF modules within low-density lipoprotein receptors (LDLRs). MESD modulates the Wnt pathway through chaperoning the coreceptors LRP5 and LRP6, to the plasma membrane and is essential for establishing embryonic polarity and mesoderm induction. MESD is expressed in many tissues, but is absent in skeletal muscle.
      Product Information
      • HEK293 cell lysate
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect LDLR chaperone MESD using this mouse monoclonal antibody, Anti-MESD Antibody, clone N88/12C validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected MESD in 10 µg of PC12 cell lysate.
      Immunohistochemistry Analysis: A 1:100-2,000 dilution from a representative lot detected MESD in rat brain and human kidney tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse MESD.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Mesdc2
      • Mesd
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 26 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected MESD in 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information