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MABE544 | Anti-MCM3, clone EPR7080, Rabbit Monoclonal Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC Rb Unpurified Monoclonal Antibody
      Catalogue NumberMABE544
      DescriptionAnti-MCM3, clone EPR7080, Rabbit Monoclonal Antibody
      Alternate Names
      • DNA replication licensing factor MCM3
      • DNA polymerase alpha holoenzyme-associated protein P1
      • P1-MCM3
      • RLF subunit beta
      • p102
      Background InformationDNA replication licensing factor MCM3, also known as DNA polymerase alpha holoenzyme-associated protein P1 or P1-MCM3 or RLF subunit beta or p102, and encoded by the gene name MCM3, is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and the recruitment of other DNA replication related proteins. MCM3 is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. MCM3 also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected MCM3 in human colon tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human MCM3.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • MCM3
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~100 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in L6, C6, RAW264.7, PC-12, NIH/3T3, HeLa, K562, HepG2, U937 and HEK293 cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected MCM3 in L6, C6, RAW264.7, PC-12, NIH/3T3, HeLa, K562, HepG2, U937, and HEK293 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies