A part of MilliporeSigma

ABD131 | Anti-MATN1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IHC, IF Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABD131
      DescriptionAnti-MATN1 Antibody
      Alternate Names
      • Matrilin 1
      • Cartilage matrix protein
      • CMP
      • CRTM
      Background InformationMatrilin 1 (MATN1), also known as cartilage matrix protein (CMP), is a member of a growing family of non-collagen-like extra-cellular matrix (ECM) proteins that play important roles in controlling the cellular phenotypes of developing mesenchymal stems cells (MSCs) during chondrocyte development. MATN1 is highly expressed in cartilage during chondrogenesis and was thought to play a role in cartilage structure; however, studies with knockout mice do not show any significant defects in cartilage or extracellular matrix structure. This is likely because its brother protein MATN3, which is also expressed in the identical window as MATN1, can replace MATN1 function. MATN1/MATN3 double mutants do show abnormalities in their cartilage. Polymorphisms within the MATN1 gene have been associated with inherited diseases associated with cartilage and chondrodysplasias including Adolescent idiopathic scoliosis (AIS), particularly in Asian populations. EMD Millipore’s Anti-MATN1 rabbit polyclonal antibody has been tested in western blotting, immunohistochemistry, and immunofluorescence in human and rat samples.
      Product Information
      FormatAffinity Purified
      • Rat liver tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      ApplicationDetect Matrilin 1 using this rabbit polyclonal antibody, Anti-MATN1 Antibody validated for use in western blotting, IHC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 5 µg/mL from a representative lot detected MATN1 in human liver tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected MATN1 in human liver tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human MATN1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the C-terminus of MATN1.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • MATN1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~57 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat liver tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected MATN1 in 15 µg of rat liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information