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MABN1176 | Anti-MAPK10, clone 10E4A4 Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ICC M Ascites Monoclonal Antibody
      Catalogue NumberMABN1176
      DescriptionAnti-MAPK10, clone 10E4A4 Antibody
      Alternate Names
      • Mitogen-activated protein kinase 10
      • MAP kinase 10
      • MAPK 10
      • MAPK10
      Background Informationmitogen-activated protein kinase 10 (MAPK10), also known as JNK3, JNK3A, PRKM10, p54bSAPK, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK10 is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
      Product Information
      PresentationMouse monoclonal IgG1ascitic fluid containing 0.03% sodium azide.
      ApplicationAnti-MAPK10, clone 10E4A4 Antibody is an antibody against MAPK10 for use in Immunocytochemistry.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenPurified recombinant fragment of human MAPK10 expressed in E. Coli.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • MAPK10
      • JNK3
      • JNK3A
      • PRKM10
      • SAPK1B
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight53 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunocytochemistry Analysis (ICC): A 1:200-1,000 dilution from a representative lot detected MAPK10 in A431 and HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies