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MABS813 | Anti-MAP2K2, clone 7F5 Antibody

MABS813
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, ICC, FC M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMABS813
      Replaces04-377
      DescriptionAnti-MAP2K2, clone 7F5 Antibody
      Alternate Names
      • Dual specificity mitogen-activated protein kinase kinase 2
      • MAP kinase kinase 2
      • MAPKK 2
      • MAP2K2
      Background InformationDual specificity mitogen-activated protein kinase kinase 2 (MAP2K2), also called MEK2, is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
      References
      Product Information
      FormatAscites
      PresentationMouse monoclonal IgG1ascitic fluid containing 0.03% sodium azide.
      Applications
      ApplicationAnti-MAP2K2, clone 7F5 Antibody is an antibody against MAP2K2 for use in Western Blotting, Immunocytochemistry, Flow Cytometry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Flow Cytometry
      Application NotesImmunocytochemistry Analysis (ICC): A 1:200-1,000 dilution from a representative lot detected MAP2K2 in HeLa cells.

      Flow Cytometry Analysis (FC): A 1:200-400 dilution from a representative lot detected MAP2K2 in HeLa cells.

      Biological Information
      ImmunogenPurified recombinant fragment of human MAP2K2 expressed in E. Coli.
      Clone7F5
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • MAP2K2
      • MEK2
      • MKK2
      • PRKMK2
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~48 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC-12, Jurkat, HeLa and NIH/3T3 cell lysates.

      Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected MAP2K2 in PC-12, Jurkat, HeLa and NIH/3T3 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

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      Catalog Number Description  
      04-377 Anti-MEK2 NT Antibody, rabbit monoclonal Show Pricing & Availability

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies